Reactome | IQGAPs bind CALM1

IQGAPs bind CALM1

Stable Identifier

R-HSA-5626549

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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IQGAP proteins IQGAP1, IQGAP2 and IQGAP3 possess IQ repeats (isoleucine- and glutamine-rich motifs) that bind CALM1 (calmodulin) in the presence of calcium ions (Atcheson et al. 2011, Andrews et al. 2012). IQGAP1 also binds the calmodulin-related proteins myosin essential light chain (MLCS1A) and S100B (Atcheson et al. 2011). Calmodulin binding inhibits the association of IQGAPs with the F-actin (Bashour et al. 1997, Pelikan-Conchaudron et al. 2011).

Literature References

PubMed ID	Title	Journal	Year
9199170	IQGAP1, a Rac- and Cdc42-binding protein, directly binds and cross-links microfilaments Bloom, GS, Fullerton, AT, Hart, MJ, Bashour, AM	J. Cell Biol.	1997
21730051	The IQGAP1 protein is a calmodulin-regulated barbed end capper of actin filaments: possible implications in its function in cell migration Carlier, MF, Didry, D, Pelikan-Conchaudron, A, Le Clainche, C	J. Biol. Chem.	2011
22944912	A calcium-dependent interaction between calmodulin and the calponin homology domain of human IQGAP1 Mallon, T, Daly, C, Bradley, CA, Hamilton, E, Timson, DJ, Andrews, WJ	Mol. Cell. Biochem.	2012
21299499	IQ-motif selectivity in human IQGAP2 and IQGAP3: binding of calmodulin and myosin essential light chain Greer, B, Atcheson, E, Pathmanathan, S, Hamilton, E, Timson, DJ, Harriott, P	Biosci. Rep.	2011