IQGAP proteins IQGAP1, IQGAP2 and IQGAP3 possess IQ repeats (isoleucine- and glutamine-rich motifs) that bind CALM1 (calmodulin) in the presence of calcium ions (Atcheson et al. 2011, Andrews et al. 2012). IQGAP1 also binds the calmodulin-related proteins myosin essential light chain (MLCS1A) and S100B (Atcheson et al. 2011). Calmodulin binding inhibits the association of IQGAPs with the F-actin (Bashour et al. 1997, Pelikan-Conchaudron et al. 2011).
Bloom, GS, Fullerton, AT, Hart, MJ, Bashour, AM
Carlier, MF, Didry, D, Pelikan-Conchaudron, A, Le Clainche, C
Mallon, T, Daly, C, Bradley, CA, Hamilton, E, Timson, DJ, Andrews, WJ
Greer, B, Atcheson, E, Pathmanathan, S, Hamilton, E, Timson, DJ, Harriott, P
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