IQGAPs bind CALM1

Stable Identifier
R-HSA-5626549
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
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IQGAPs bind CALM1
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IQGAP proteins IQGAP1, IQGAP2 and IQGAP3 possess IQ repeats (isoleucine- and glutamine-rich motifs) that bind CALM1 (calmodulin) in the presence of calcium ions (Atcheson et al. 2011, Andrews et al. 2012). IQGAP1 also binds the calmodulin-related proteins myosin essential light chain (MLCS1A) and S100B (Atcheson et al. 2011). Calmodulin binding inhibits the association of IQGAPs with the F-actin (Bashour et al. 1997, Pelikan-Conchaudron et al. 2011).

Literature References
PubMed ID Title Journal Year
21730051 The IQGAP1 protein is a calmodulin-regulated barbed end capper of actin filaments: possible implications in its function in cell migration

Pelikan-Conchaudron, A, Le Clainche, C, Didry, D, Carlier, MF

J. Biol. Chem. 2011
9199170 IQGAP1, a Rac- and Cdc42-binding protein, directly binds and cross-links microfilaments

Bashour, AM, Fullerton, AT, Hart, MJ, Bloom, GS

J. Cell Biol. 1997
22944912 A calcium-dependent interaction between calmodulin and the calponin homology domain of human IQGAP1

Andrews, WJ, Bradley, CA, Hamilton, E, Daly, C, Mallon, T, Timson, DJ

Mol. Cell. Biochem. 2012
21299499 IQ-motif selectivity in human IQGAP2 and IQGAP3: binding of calmodulin and myosin essential light chain

Atcheson, E, Hamilton, E, Pathmanathan, S, Greer, B, Harriott, P, Timson, DJ

Biosci. Rep. 2011
Participants
Input
Output
Participant Of
hasEvent
Orthologous Events
IQGAPs bind CALM1 (Bos taurus)
IQGAPs bind CALM1 (Caenorhabditis elegans)
IQGAPs bind CALM1 (Canis familiaris)
IQGAPs bind CALM1 (Dictyostelium discoideum)
IQGAPs bind CALM1 (Mus musculus)
IQGAPs bind CALM1 (Rattus norvegicus)
IQGAPs bind CALM1 (Saccharomyces cerevisiae)
IQGAPs bind CALM1 (Schizosaccharomyces pombe)
IQGAPs bind CALM1 (Sus scrofa)
IQGAPs bind CALM1 (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2014-10-24)
Rivero Crespo, F  (2014-12-26)
Created
Orlic-Milacic, M  (2014-10-10)