IQGAP proteins IQGAP1, IQGAP2 and IQGAP3 possess IQ repeats (isoleucine- and glutamine-rich motifs) that bind CALM1 (calmodulin) in the presence of calcium ions (Atcheson et al. 2011, Andrews et al. 2012). IQGAP1 also binds the calmodulin-related proteins myosin essential light chain (MLCS1A) and S100B (Atcheson et al. 2011). Calmodulin binding inhibits the association of IQGAPs with the F-actin (Bashour et al. 1997, Pelikan-Conchaudron et al. 2011).
Pelikan-Conchaudron, A, Le Clainche, C, Didry, D, Carlier, MF
Bashour, AM, Fullerton, AT, Hart, MJ, Bloom, GS
Andrews, WJ, Bradley, CA, Hamilton, E, Daly, C, Mallon, T, Timson, DJ
Atcheson, E, Hamilton, E, Pathmanathan, S, Greer, B, Harriott, P, Timson, DJ
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