CIT (citron kinase) binds activated RHOA, RHOB, RHOC and RAC1

Stable Identifier
R-HSA-5625901
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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CIT (citron kinase) binds activated RHOA, RHOB, RHOC and RAC1
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Citron kinase CIT was identified as a RHO GTPase effector in a yeast two hybrid screen, where it was shown, using mouse proteins, that CIT strongly binds GTP-bound RHOA, RHOB, RHOC and RAC1, but not CDC42. CIT possesses a centrally located Rho/Rac binding domain, while the kinase domain is located at the N-terminus. CIT is likely a homodimer that is activated by a conformational change upon RHO/RAC1 binding (Madaule et al. 1995).
Literature References
PubMed ID Title Journal Year
8543060 A novel partner for the GTP-bound forms of rho and rac

Madaule, P, Narumiya, S, Furuyashiki, T, Watanabe, G, Reid, T, Ishizaki, T, Morii, N

FEBS Lett. 1995
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
CIT:CDKN1B [cytosol] (Homo sapiens)
Active Unit
CDKN1B [cytosol]
Inferred From
Cit binds activated Rhoa, Rhob, Rhoc and Rac1 (Mus musculus)
Authored
Orlic-Milacic, M  (2014-10-24)
Rivero Crespo, F  (2014-12-26)
Created
Orlic-Milacic, M  (2014-10-08)
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