Reactome | SOX3 [nucleoplasm]

SOX3 [nucleoplasm]

Stable Identifier

R-HSA-5625835

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Transcription factor SOX-3, SOX3_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by WNT (Homo sapiens)
  - TCF dependent signaling in response to WNT (Homo sapiens)
    - Deactivation of the beta-catenin transactivating complex (Homo sapiens)
      - Beta-catenin binds SOX proteins (Homo sapiens)
        
        CTNNB1:SRY,SOX2,SOX3,SOX4,SOX6,SOX7,SOX9,SOX17 [nucleoplasm] (Homo sapiens)
        
        SRY,SOX2,SOX3,SOX4,SOX6,SOX7,SOX9,SOX17 [nucleoplasm] (Homo sapiens)
        
        SOX3 [nucleoplasm] (Homo sapiens)
        
        SRY,SOX2,SOX3,SOX4,SOX6,SOX7,SOX9,SOX17 [nucleoplasm] (Homo sapiens)
        
        SOX3 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P41225 SOX3

Gene Names

SOX3

Chain

chain:1-446

Reference Genes

BioGPS Gene:6658 SOX3

COSMIC (genes):SOX3 SOX3

CTD Gene:6658 SOX3

dbSNP Gene:6658 SOX3

ENSEMBL:ENSG00000134595 SOX3

HGNC:11199 SOX3

KEGG Gene (Homo sapiens):6658 SOX3

Monarch:6658 SOX3

NCBI Gene:6658 SOX3

OMIM:313430 SOX3

UCSC:P41225 SOX3

Reference Transcript

RefSeq:NM_005634.2 SOX3

Other Identifiers

0002940142

11735343_at

11735344_at

1553802_a_at

17114690

214633_at

4024311

4024312

4024313

4024314

4024315

4024316

4024317

4024318

4024319

4024320

4024321

40531_at

6658

8175528

ADDON002770.hg

A_24_P113725

GE56543

GE80283

GO:0000003

GO:0000122

GO:0000785

GO:0000978

GO:0000981

GO:0003674

GO:0003677

GO:0003700

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005694

GO:0006355

GO:0007275

GO:0007417

GO:0007423

GO:0007530

GO:0008150

GO:0009058

GO:0009653

GO:0021854

GO:0021983

GO:0030154

GO:0034641

GO:0043226

GO:0045665

GO:0045944

GO:0048856

GO:0060324

GO:1990837

HMNXSV003037899

Hs.157429.0.S2_3p_at

Hs2.157429.1.A1_3p_s_at

ILMN_1653055

PH_hs_0009530

TC0X001433.hg

TC0X002254.hg

X71135_at

Participates

as a member of

SRY,SOX2,SOX3,SOX4,SOX6,SOX7,SOX9,SOX17 [nucleoplasm] (Homo sapiens)

Inferred To

sox-4 [nucleoplasm] (Caenorhabditis elegans)

SOX3 [nucleoplasm] (Canis familiaris)

SOX3 [nucleoplasm] (Sus scrofa)

Sox14 [nucleoplasm] (Drosophila melanogaster)

SoxN [nucleoplasm] (Drosophila melanogaster)

D [nucleoplasm] (Drosophila melanogaster)

sox-2 [nucleoplasm] (Caenorhabditis elegans)

sox-3 [nucleoplasm] (Caenorhabditis elegans)

sox3 [nucleoplasm] (Danio rerio)

sox3 [nucleoplasm] (Xenopus tropicalis)

Sox21b [nucleoplasm] (Drosophila melanogaster)

sem-2 [nucleoplasm] (Caenorhabditis elegans)

Sox21a [nucleoplasm] (Drosophila melanogaster)

Sox3 [nucleoplasm] (Mus musculus)

Homologues of SOX3 [nucleoplasm] (Caenorhabditis elegans)

Homologues of SOX3 [nucleoplasm] (Drosophila melanogaster)

Sox15 [nucleoplasm] (Drosophila melanogaster)

Cross References

RefSeq

NP_005625.2

OpenTargets

ENSG00000134595

GeneCards

P41225

HPA

ENSG00000134595-SOX3

Ensembl

ENST00000370536, ENSG00000134595, ENSP00000359567

PRO

P41225

Pharos - Targets

P41225

Orphanet

16787

GlyGen

P41225

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q12933 TRAF2	5	TRAF2 [nucleoplasm] (R-HSA-8862199) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) TRAF2 [cytosol] (R-HSA-66370)	0.556	3