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Phosphorylated PKN1 binds androgen receptor (AR)
Stable Identifier
R-HSA-5625717
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
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Signal Transduction (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase Effectors (Homo sapiens)
RHO GTPases activate PKNs (Homo sapiens)
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 (Homo sapiens)
Phosphorylated PKN1 binds androgen receptor (AR) (Homo sapiens)
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Activated PKN1 binds androgen-activated AR (androgen receptor) (Metzger et al. 2003).
Literature References
PubMed ID
Title
Journal
Year
12514133
A novel inducible transactivation domain in the androgen receptor: implications for PRK in prostate cancer
Schüle, R
,
Metzger, E
,
Müller, JM
,
Ferrari, S
,
Buettner, R
EMBO J.
2003
Participants
Input
AR:Androgens [cytosol]
(Homo sapiens)
p-T774-PKN1 [cytosol]
(Homo sapiens)
Output
p-T774-PKN1:AR:Androgen [cytosol]
(Homo sapiens)
Participates
as an event of
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 (Homo sapiens)
Orthologous Events
Phosphorylated PKN1 binds androgen receptor (AR) (Bos taurus)
Phosphorylated PKN1 binds androgen receptor (AR) (Canis familiaris)
Phosphorylated PKN1 binds androgen receptor (AR) (Danio rerio)
Phosphorylated PKN1 binds androgen receptor (AR) (Drosophila melanogaster)
Phosphorylated PKN1 binds androgen receptor (AR) (Mus musculus)
Phosphorylated PKN1 binds androgen receptor (AR) (Rattus norvegicus)
Phosphorylated PKN1 binds androgen receptor (AR) (Sus scrofa)
Authored
Orlic-Milacic, M (2014-10-24)
Rivero Crespo, F (2014-12-26)
Created
Orlic-Milacic, M (2014-10-07)
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