Reactome | PDE6D [cilium]

PDE6D [cilium]

Stable Identifier

R-HSA-5624884

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cilium

Synonyms

Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta, PDE6D_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:O43924 PDE6D

Gene Names

PDE6D, PDED

Chain

chain:1-150

Reference Genes

BioGPS Gene:5147 PDE6D

COSMIC (genes):PDE6D PDE6D

CTD Gene:5147 PDE6D

dbSNP Gene:5147 PDE6D

ENSEMBL:ENSG00000156973 PDE6D

HGNC:8788 PDE6D

KEGG:hsa:5147 PDE6D

Monarch:5147 PDE6D

NCBI Gene:5147 PDE6D

OMIM:602676 PDE6D

UCSC:O43924 PDE6D

Reference Transcript

Other Identifiers

11719200_a_at

11719201_at

16909537

204091_PM_at

204091_at

216883_PM_x_at

216883_x_at

231065_PM_at

231065_at

2603605

2603606

2603607

2603610

2603611

2603612

2603613

2603614

2603615

2603625

2603626

2603627

2603628

2603630

2603631

36044_at

5147

76583_at

8059731

A_23_P102517

GE54175

GO:0005095

GO:0005515

GO:0005737

GO:0005829

GO:0005856

GO:0005929

GO:0007601

GO:0016020

GO:0030659

GO:0031267

GO:0031410

GO:0042995

GO:0043226

GO:0050877

GO:0050953

GO:0098772

HMNXSV003001727

HMNXSV003003488

Hs.129450.0.A1_3p_at

Hs.48291.1.A1_3p_a_at

ILMN_1790680

PH_hs_0031215

TC02002867.hg

TC02004851.hg

Participates

as a component of

as an output of

PDE6D dissociates from ARL13B:INPP5E (Homo sapiens)

Other forms of this molecule

PDE6D [cytosol]

Inferred To

PDE6D [cilium] (Bos taurus)

PDE6D [cilium] (Canis familiaris)

PDE6D [cilium] (Gallus gallus)

PDE6D [cilium] (Sus scrofa)

Pde6d [cilium] (Mus musculus)

Pde6d [cilium] (Rattus norvegicus)

Cross References

RefSeq

NP_002592.1, NP_001277947.1

ZINC - World Drugs

PDE6D_HUMAN

Guide to Pharmacology - Targets

1315

OpenTargets

ENSG00000156973

ENSEMBL

ENST00000287600, ENSP00000287600

ZINC - FDA approved

PDE6D_HUMAN

ZINC - Substances

PDE6D_HUMAN

ZINC target

O43924

PRO

O43924

PDB

7PAD, 5ML3, 1KSG, 5X73, 1KSH, 5ML2, 7PAE, 5X72, 1KSJ, 4JVF, 3T5I, 4JVB, 3T5G, 4JV8, 5ML4, 5X74, 5ML6, 5E80, 5TAR, 7Q9Q, 5ML8, 5NAL, 5YAV, 7Q9R, 5TB5, 7QJK, 5YAW, 7QF9, 7Q9S, 7Q9U, 4JV6, 5E8F, 7PAC, 4JHP, 5F2U

HPA

ENSG00000156973-PDE6D

Pharos - Targets

O43924

Orphanet

PDE6D

ZINC - Predictions - Purchasable

PDE6D_HUMAN

HMDB Protein

HMDBP00641

Interactors (18)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P36404 ARL2	2	ARL2 [mitochondrial matrix] (R-HSA-5250216) ARL2 [cytosol] (R-HSA-5216230)	0.955	19
UniProt:P36405 ARL3	1	ARL3 [cilium] (R-HSA-5618182)	0.922	11
UniProt:Q92834 RPGR			0.859	13
UniProt:Q0P5N6 ARL16			0.795	13
UniProt:Q9NRR6 INPP5E	2	INPP5E [cilium] (R-HSA-5624872) INPP5E [cytosol] (R-HSA-1604585)	0.725	5
UniProt:P51157 RAB28			0.725	5
UniProt:Q9D0J4	2	ARL2 [mitochondrial matrix] (R-MMU-5250216) ARL2 [cytosol] (R-MMU-5216230)	0.71	6
UniProt:Q9NXU5 ARL15			0.666	4
UniProt:Q92834-2 RPGR			0.659	3
UniProt:Q15382-PRO_0000082708 RHEB			0.645	5
UniProt:Q9WUL7	1	ARL3 [cilium] (R-MMU-5618182)	0.602	4
UniProt:Q5XKR4 OTP			0.556	3
UniProt:Q8IW50 F219A			0.547	2
UniProt:Q9BXI6 TBC1D10A	2	TBC1D10A [cytosol] (R-HSA-8854139) TBC1D10A [microvillus] (R-HSA-8854143)	0.527	3
UniProt:Q03252 LMNB2			0.527	3
UniProt:Q9UK96 FBXO10	1	FBXO10 [cytosol] (R-HSA-8862618)	0.527	3
UniProt:P51153 RAB13	4	GGC-RAB13 [cytoplasmic vesicle membrane] (R-HSA-1445110) GGC-RAB13 [cell junction] (R-HSA-8876591) GGC-RAB13 [cytosol] (R-HSA-8873767) RAB13 [cytosol] (R-HSA-8873674)	0.508	2
UniProt:Q7DB77 TIR			0.508	3