Reactome | SFKs phosphorylates RAF1 on Y340,Y341

SFKs phosphorylates RAF1 on Y340,Y341

Stable Identifier

R-HSA-5624486

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

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Phosphorylation of tyrosine 340, 341 (Y340,341) on RAF1 in response to CD209 (DC-SIGN) signalling depends on yet unidentified members of the Src family of tyrosine kinases (SFKs). In imunoprecipitation studies, CD209 from lipid rafts of dendritic cells was found to co-precipitate with LYN, a member of the SFK, as well as with SYK tyrosine kinase, indicating their possible involvement in DC-SIGN signalling (Caparros et al. 2006, Svajger et al. 2010).

Literature References

PubMed ID	Title	Journal	Year
16434485	DC-SIGN ligation on dendritic cells results in ERK and PI3K activation and modulates cytokine production Caparros, E, Munoz, P, Sierra-Filardi, E, Serrano-Gómez, D, Puig-Kröger, A, Rodríguez-Fernández, JL, Mellado, M, Sancho, J, Zubiaur, M, Corbí, AL	Blood	2006
20363321	C-type lectin DC-SIGN: an adhesion, signalling and antigen-uptake molecule that guides dendritic cells in immunity Svajger, U, Anderluh, M, Jeras, M, Obermajer, N	Cell. Signal.	2010