Phosphorylation of tyrosine 340, 341 (Y340,341) on RAF1 in response to CD209 (DC-SIGN) signalling depends on yet unidentified members of the Src family of tyrosine kinases (SFKs). In imunoprecipitation studies, CD209 from lipid rafts of dendritic cells was found to co-precipitate with LYN, a member of the SFK, as well as with SYK tyrosine kinase, indicating their possible involvement in DC-SIGN signalling (Caparros et al. 2006, Svajger et al. 2010).
Caparros, E, Munoz, P, Sierra-Filardi, E, Serrano-Gómez, D, Puig-Kröger, A, Rodríguez-Fernández, JL, Mellado, M, Sancho, J, Zubiaur, M, Corbí, AL
Svajger, U, Anderluh, M, Jeras, M, Obermajer, N
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