SFKs phosphorylates RAF1 on Y340,Y341

Stable Identifier
Reaction [BlackBoxEvent]
Homo sapiens
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Phosphorylation of tyrosine 340, 341 (Y340,341) on RAF1 in response to CD209 (DC-SIGN) signalling depends on yet unidentified members of the Src family of tyrosine kinases (SFKs). In imunoprecipitation studies, CD209 from lipid rafts of dendritic cells was found to co-precipitate with LYN, a member of the SFK, as well as with SYK tyrosine kinase, indicating their possible involvement in DC-SIGN signalling (Caparros et al. 2006, Svajger et al. 2010).

Literature References
PubMed ID Title Journal Year
20363321 C-type lectin DC-SIGN: an adhesion, signalling and antigen-uptake molecule that guides dendritic cells in immunity

Obermajer, N, Svajger, U, Anderluh, M, Jeras, M

Cell. Signal. 2010
16434485 DC-SIGN ligation on dendritic cells results in ERK and PI3K activation and modulates cytokine production

Munoz, P, Corbí, AL, Serrano-Gómez, D, Puig-Kröger, A, Rodríguez-Fernández, JL, Mellado, M, Sierra-Filardi, E, Zubiaur, M, Sancho, J, Caparros, E

Blood 2006
Catalyst Activity

protein tyrosine kinase activity of FYN, LYN [cytosol]

Orthologous Events
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