Phosphorylation of tyrosine 340, 341 (Y340,341) on RAF1 in response to CD209 (DC-SIGN) signalling depends on yet unidentified members of the Src family of tyrosine kinases (SFKs). In imunoprecipitation studies, CD209 from lipid rafts of dendritic cells was found to co-precipitate with LYN, a member of the SFK, as well as with SYK tyrosine kinase, indicating their possible involvement in DC-SIGN signalling (Caparros et al. 2006, Svajger et al. 2010).
Obermajer, N, Svajger, U, Anderluh, M, Jeras, M
Munoz, P, Corbí, AL, Serrano-Gómez, D, Puig-Kröger, A, Rodríguez-Fernández, JL, Mellado, M, Sierra-Filardi, E, Zubiaur, M, Sancho, J, Caparros, E
protein tyrosine kinase activity of FYN, LYN [cytosol]
© 2022 Reactome
