Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
TIAM2 [cytosol]
Stable Identifier
R-HSA-561165
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
T-lymphoma invasion and metastasis-inducing protein 2, TIAM2_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Regulation of lipid metabolism by PPARalpha (Homo sapiens)
PPARA activates gene expression (Homo sapiens)
Expression of TIAM2 (Homo sapiens)
TIAM2 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Death Receptor Signaling (Homo sapiens)
p75 NTR receptor-mediated signalling (Homo sapiens)
Cell death signalling via NRAGE, NRIF and NADE (Homo sapiens)
NRAGE signals death through JNK (Homo sapiens)
p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Homo sapiens)
GEFs [cytosol] (Homo sapiens)
TIAM2 [cytosol] (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (12/13) signalling events (Homo sapiens)
GEFs activate RhoA,B,C (Homo sapiens)
GEFs [cytosol] (Homo sapiens)
TIAM2 [cytosol] (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase cycle (Homo sapiens)
RAC1 GTPase cycle (Homo sapiens)
RAC1 GEFs activate RAC1 (Homo sapiens)
RAC1 GEFs [cytosol] (Homo sapiens)
TIAM2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8IVF5 TIAM2
Gene Names
TIAM2, KIAA2016, STEF
Chain
initiator methionine:1, chain:2-1701
Reference Genes
BioGPS Gene:26230 TIAM2
COSMIC (genes):TIAM2 TIAM2
CTD Gene:26230 TIAM2
dbSNP Gene:26230 TIAM2
ENSEMBL:ENSG00000146426 TIAM2
HGNC:11806 TIAM2
KEGG:hsa:26230 TIAM2
Monarch:26230 TIAM2
NCBI Entrez Gene:26230 TIAM2
OMIM:604709 TIAM2
UCSC:Q8IVF5 TIAM2
Reference Transcript
RefSeq:NM_012454.3 TIAM2
RefSeq:NM_001010927.3 TIAM2
RefSeq:NM_001384547.1 TIAM2
RefSeq:NM_001384546.1 TIAM2
Other Identifiers
11737763_a_at
11749638_a_at
17013954
222942_PM_s_at
222942_s_at
227866_PM_at
227866_at
26230
2932425
2932426
2932440
2932441
2932442
2932446
2932447
2932453
2932458
2932509
2932511
2932512
2932514
2932515
2932516
2932517
2932518
2932519
2932520
2932525
2932526
2932527
2932535
2932536
2932537
2932540
2932541
2932542
2932543
2932544
2932554
2932556
2932557
2932560
2932563
2932564
2932566
2932568
2932569
2932570
2932571
2932573
2932576
2932578
2932579
2932580
2932581
2932583
2932584
2932585
2932586
2932587
52820_at
60892_at
60903_s_at
67274_at
8122933
A_14_P106889
A_14_P119739
A_14_P201737
A_19_P00321110
A_19_P00322325
A_24_P303454
A_33_P3282374
GE63054
GE79657
GO:0005085
GO:0005096
GO:0005515
GO:0005737
GO:0005829
GO:0007165
GO:0007264
GO:0016020
GO:0030027
GO:0030175
GO:0030426
GO:0035556
GO:0042995
GO:0043005
GO:0043204
GO:0045202
GO:0050772
GO:0051056
GO:0070062
GO:0090630
GO:0098772
HMNXSV003002703
HMNXSV003029065
HMNXSV003046855
Hs.12598.0.A1_3p_a_at
Hs.3737.0.A1_3p_at
ILMN_1681675
ILMN_1740627
ILMN_2358560
PH_hs_0000426
PH_hs_0026677
TC06003140.hg
TC06003141.hg
TC06004104.hg
p26379
Participates
as a member of
RAC1 GEFs [cytosol] (Homo sapiens)
GEFs [cytosol] (Homo sapiens)
as an output of
Expression of TIAM2 (Homo sapiens)
Inferred To
gxcF [cytosol]
(Dictyostelium discoideum)
tiam-1 [cytosol]
(Caenorhabditis elegans)
Tiam2 [cytosol]
(Mus musculus)
Tiam2 [cytosol]
(Rattus norvegicus)
TIAM2 [cytosol]
(Bos taurus)
TIAM2 [cytosol]
(Canis familiaris)
TIAM2 [cytosol]
(Gallus gallus)
TIAM2 [cytosol]
(Sus scrofa)
sif [cytosol]
(Drosophila melanogaster)
Cross References
RefSeq
NP_001371476.1
,
NP_001010927.2
,
NP_001371475.1
,
NP_036586.2
ENSEMBL
ENST00000360366
,
ENST00000529824
,
ENSG00000146426
,
ENST00000682666
,
ENST00000275246
,
ENSP00000353528
,
ENSP00000507157
,
ENST00000461783
,
ENSP00000437188
,
ENST00000456877
,
ENSP00000275246
,
ENSP00000433348
,
ENSP00000407183
OpenTargets
ENSG00000146426
GeneCards
TIAM2
HPA
ENSG00000146426-TIAM2
PRO
Q8IVF5
Pharos - Targets
Q8IVF5
GlyGen
Q8IVF5
HMDB Protein
HMDBP08609
© 2025
Reactome
This website requires cookies and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our
Privacy Notice
.
I agree, dismiss this banner
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text