CLEC7A binds 1,3-beta-D-glucan

Stable Identifier
R-HSA-5607758
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Synonyms
Dectin-1 binds 1,3-beta-D-glucan
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CLEC7A (Dectin-1) was identified as a primary receptor for beta-glucans from fungi, bacteria, and plants and specifically recognises beta 1-3 linked glucans. Human CLEC7A has eight alternatively splice products of which only two are functional for beta-glucan binding (isoforms A and B) (Willment et al. 2001). CLEC7A possesses an extracellular C-type lectin-like domain (CTLD) that is connected by a stalk region to a transmembrane domain and cytoplasmic tail, which contains an immunoreceptor tyrosine-based activation (ITAM)-like motif. Two highly conserved amino acids (222W 224H in Human; 221W, 223H in Mouse) within the CTLD which have been identified as essential for beta-glucan binding (Brown et al. 2007, Adachi et al. 2004). Through the recognition of beta-glucans, CLEC7A binds several fungal species such as Aspergillus, Candida, Coccidioides, Pencillium, Pneumocystis and Saccharimyces.
Ferwerda et al. (2009) suggest that chronic mucocutaneous candidiasis may be caused by a genetic defect of CLEC7A. The mutation of nucleotide A-->C causes a change of amino acid 238 from tyrosine to a stop codon (Tyr238*), leading to the loss of the last nine amino acids of the carbohydrate-recognition domain (CRD). This mutated form of CLEC7A is poorly expressed and does not mediate beta-glucan binding, leading to defective production of cytokines after stimulation with beta-glucans or Candida albicans (Ferwerda et al. 2009).

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