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TRAF6 oligomerizes
Stable Identifier
R-HSA-5607751
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane
,
cytosol
ReviewStatus
5/5
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Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
C-type lectin receptors (CLRs) (Homo sapiens)
CLEC7A (Dectin-1) signaling (Homo sapiens)
TRAF6 oligomerizes (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The MALT1 oligomers bound to TRAF6 induce TRAF6 oligomerization and activate TRAF6 E3 ubiquitin ligase activity (Sun et al. 2004).
Literature References
PubMed ID
Title
Journal
Year
15125833
The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MALT1 in T lymphocytes
Deng, L
,
Chen, ZJ
,
Sun, L
,
Xia, ZP
,
Ea, CK
Mol Cell
2004
Participants
Input
p-T231-CARD9:BCL10:MALT1 oligomers:TRAF6 [plasma membrane]
(Homo sapiens)
x 2
TRAF6 [cytosol]
(Homo sapiens)
Output
p-T231-CARD9:BCL10:MALT1:TRAF6 oligomers [plasma membrane]
(Homo sapiens)
Participates
as an event of
CLEC7A (Dectin-1) signaling (Homo sapiens)
Orthologous Events
TRAF6 oligomerizes (Bos taurus)
TRAF6 oligomerizes (Canis familiaris)
TRAF6 oligomerizes (Gallus gallus)
TRAF6 oligomerizes (Mus musculus)
TRAF6 oligomerizes (Rattus norvegicus)
TRAF6 oligomerizes (Sus scrofa)
Authored
Garapati, P V (2014-07-14)
Reviewed
Geijtenbeek, TB (2014-09-02)
Created
Garapati, P V (2014-07-14)
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