Activation of SYK triggers multiple cascades, which induces NF-kB activation through a CARD9-dependent pathway. Phospholipase C-gamma 2 (PLCG2) is one of the key signaling components of the CLEC7A (Dectin-1) pathway that connects SYK activation to CARD9 recruitment. PLCG2 is activated upon CLEC7A engagement and triggers an intracellular Ca2+ flux. SYK and Src family kinases are upstream of PLCG2 (Xu et al. 2009, Tassi et al. 2009, Gorjestani et al. 2011). SYK phosphorylates PLCG2 on Y753 and Y759, enhancing the activity of PLCG2 (Suzuki-Inoue et al. 2004).