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p52:RELB translocates from cytosol to nucleus
Stable Identifier
R-HSA-5607741
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
,
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
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Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
TNFR2 non-canonical NF-kB pathway (Homo sapiens)
NIK-->noncanonical NF-kB signaling (Homo sapiens)
p52:RELB translocates from cytosol to nucleus (Homo sapiens)
Innate Immune System (Homo sapiens)
C-type lectin receptors (CLRs) (Homo sapiens)
CLEC7A (Dectin-1) signaling (Homo sapiens)
Dectin-1 mediated noncanonical NF-kB signaling (Homo sapiens)
p52:RELB translocates from cytosol to nucleus (Homo sapiens)
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Following 26S-proteasomal processing, NFKB2 p52:RELB dimer is translocated from cytosol into the nucleus where it stimulates expression of target genes (Lin & Karin 2003). Dectin-1 induced RELB-p52 triggers the transcription of chemokines C-C motif chemokine 17 (CCL17) and CCL22 and repression of interleukin 12B (IL12B) transcription (Gringhuis et al. 2009).
Literature References
PubMed ID
Title
Journal
Year
8921937
Differential nuclear localization of p50, p52, and RelB proteins in human accessory cells of the immune response in situ
Israël, A
,
Raphael, M
,
Körner, M
,
Vassy, J
,
Feuillard, J
Eur. J. Immunol.
1996
Participants
Input
p52:RELB [cytosol]
(Homo sapiens)
Output
p52:RELB [nucleoplasm]
(Homo sapiens)
Participates
as an event of
NIK-->noncanonical NF-kB signaling (Homo sapiens)
Dectin-1 mediated noncanonical NF-kB signaling (Homo sapiens)
Orthologous Events
p52:RELB translocates from cytosol to nucleus (Bos taurus)
p52:RELB translocates from cytosol to nucleus (Canis familiaris)
p52:RELB translocates from cytosol to nucleus (Drosophila melanogaster)
p52:RELB translocates from cytosol to nucleus (Mus musculus)
p52:RELB translocates from cytosol to nucleus (Rattus norvegicus)
p52:RELB translocates from cytosol to nucleus (Sus scrofa)
Authored
Garapati, P V (2014-07-14)
Reviewed
Geijtenbeek, TB (2014-09-02)
Created
Garapati, P V (2014-07-14)
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