Reactome | p52:RELB translocates from cytosol to nucleus

p52:RELB translocates from cytosol to nucleus

Stable Identifier

R-HSA-5607741

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm, cytosol

Locations in the PathwayBrowser

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Immune System (Homo sapiens)

- Cytokine Signaling in Immune system (Homo sapiens)
  - TNFR2 non-canonical NF-kB pathway (Homo sapiens)
    - NIK-->noncanonical NF-kB signaling (Homo sapiens)
      - p52:RELB translocates from cytosol to nucleus (Homo sapiens)
- Innate Immune System (Homo sapiens)
  - C-type lectin receptors (CLRs) (Homo sapiens)
    - CLEC7A (Dectin-1) signaling (Homo sapiens)
      - Dectin-1 mediated noncanonical NF-kB signaling (Homo sapiens)
        
        p52:RELB translocates from cytosol to nucleus (Homo sapiens)

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p52:RELB translocates from cytosol to nucleus

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Following 26S-proteasomal processing, NFKB2 p52:RELB dimer is translocated from cytosol into the nucleus where it stimulates expression of target genes (Lin & Karin 2003). Dectin-1 induced RELB-p52 triggers the transcription of chemokines C-C motif chemokine 17 (CCL17) and CCL22 and repression of interleukin 12B (IL12B) transcription (Gringhuis et al. 2009).

Literature References

PubMed ID	Title	Journal	Year
8921937	Differential nuclear localization of p50, p52, and RelB proteins in human accessory cells of the immune response in situ Feuillard, J, Körner, M, Israël, A, Vassy, J, Raphael, M	Eur. J. Immunol.	1996