Reactome | K63polyUb-TAK1 autophosphorylates

K63polyUb-TAK1 autophosphorylates

Stable Identifier

R-HSA-5607732

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

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TAK1-binding protein 1 (TAB1) is a TAK1-interacting protein and induces TAK1 (Transforming growth factor beta-associated kinase 1) kinase activity through promoting autophosphorylation of key serine/threonine sites of the kinase activation loop. There are four phosphorylation sites in the activation loop and analysis of these site mutants indicate that autophosphorylation of S192, is followed by sequential phosphorylation of T178, T187, and finally T184 (Scholz et al. 2010).

Literature References

PubMed ID	Title	Journal	Year
20538596	Autoactivation of transforming growth factor beta-activated kinase 1 is a sequential bimolecular process Scholz, R, Sidler, CL, Thali, RF, Winssinger, N, Cheung, PC, Neumann, D	J. Biol. Chem.	2010