Reactome | GP9 [plasma membrane]

GP9 [plasma membrane]

Stable Identifier

R-HSA-55881

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Platelet glycoprotein IX precursor, GPIX, CD42A

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Diseases of hemostasis (Homo sapiens)
  - Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) (Homo sapiens)
    - Defective factor IX causes hemophilia B (Homo sapiens)
      - Defective F9 activation (Homo sapiens)
        
        FIX(29-461) variant is not activated (factor XIa catalyst) (Homo sapiens)
        
        factor XIa:GPIb:GPIX:GPV complex [plasma membrane] (Homo sapiens)
        
        GPIb-IX-V [plasma membrane] (Homo sapiens)
        
        GP9 [plasma membrane] (Homo sapiens)
  - Defects of platelet adhesion to exposed collagen (Homo sapiens)
    - Defective binding of VWF variant to GPIb:IX:V (Homo sapiens)
      - VWF variant does not bind GPIb:IX:V (Homo sapiens)
        
        GP1BA:GP1BB:GP9:GP5 [plasma membrane] (Homo sapiens)
        
        GP1BA:GP1BB:GP9 [plasma membrane] (Homo sapiens)
        
        GP9 [plasma membrane] (Homo sapiens)
    - Enhanced binding of GP1BA variant to VWF multimer:collagen (Homo sapiens)
      - GP1BA variant binds to VWF multimer:collagen (Homo sapiens)
        
        Collagen type I fibril:VWF multimer:GP1BA variant:GP1BB:GP9:GP5 [plasma membrane] (Homo sapiens)
        
        GP1BA variant:GP1BB:GP9:GP5 [plasma membrane] (Homo sapiens)
        
        GP1BA variant:GP1BB:GP9 [plasma membrane] (Homo sapiens)
        
        GP9 [plasma membrane] (Homo sapiens)
        
        GP1BA variant:GP1BB:GP9:GP5 [plasma membrane] (Homo sapiens)
        
        GP1BA variant:GP1BB:GP9 [plasma membrane] (Homo sapiens)
        
        GP9 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P14770 GP9

Gene Names

GP9

Chain

signal peptide:1-16, chain:17-177

Reference Genes

BioGPS Gene:2815 GP9

COSMIC (genes):GP9 GP9

CTD Gene:2815 GP9

dbSNP Gene:2815 GP9

ENSEMBL:ENSG00000169704 GP9

ENSEMBL_homo_sapiens_GENE:ENSG00000169704.5 GP9

HGNC:4444 GP9

KEGG Gene (Homo sapiens):2815 GP9

Monarch:2815 GP9

NCBI Gene:2815 GP9

OMIM:173515 GP9

UCSC:P14770 GP9

Reference Transcript

Other Identifiers

11730648_at

16945305

206883_PM_x_at

206883_x_at

2641480

2641482

2641484

2641485

2641486

2815

35101_at

8082473

A_23_P33256

A_33_P3383226

GE533113

GO:0005515

GO:0005886

GO:0007155

GO:0007596

GO:0007597

GO:0007599

GO:0010572

GO:0016020

GO:0030154

GO:0035855

GO:0042060

GO:0048856

GO:0051209

GO:0051604

GO:0055065

GO:0055085

GO:1990779

HMNXSV003020033

ILMN_1743290

M80478_at

TC03000686.hg

g4504076_3p_at

Participates

as a component of

Inferred To

Ghost homologue of GP9 [plasma membrane] (Danio rerio)

LOC116410485 [plasma membrane] (Xenopus tropicalis)

GP9 [plasma membrane] (Bos taurus)

GP9 [plasma membrane] (Gallus gallus)

GP9 [plasma membrane] (Sus scrofa)

Gp9 [plasma membrane] (Mus musculus)

Gp9 [plasma membrane] (Rattus norvegicus)

Cross References

RefSeq

XP_011511003.1, XP_011511004.1, XP_005247431.1, NP_000165.1

OpenTargets

ENSG00000169704

HPA

ENSG00000169704-GP9

GeneCards

P14770

Ensembl

ENST00000307395, ENSG00000169704, ENSP00000303942

PRO

P14770

Pharos - Targets

P14770

Orphanet

16159

PDB

3REZ

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P07359 GP1BA	6	GP1BA G249S [plasma membrane] (R-HSA-9844280) GP1BA G249V [plasma membrane] (R-HSA-9844257) GP1BA M255V [plasma membrane] (R-HSA-9844240) GP1BA [plasma membrane] (R-HSA-55861) GP1BA D251Y [plasma membrane] (R-HSA-9844197) GP1BA W246L [plasma membrane] (R-HSA-9844258)	0.787	7
UniProt:P49639 HOXA1	1	HOXA1 [nucleoplasm] (R-HSA-5617464)	0.666	4
UniProt:O43597 SPRY2	8	p-S111,S120-SPRY2 [cytosol] (R-HSA-1295590) p-Y55-SPRY2 [cytosol] (R-HSA-182950) SPRY2 [plasma membrane] (R-HSA-182924) SPRY2 [cytosol] (R-HSA-182949) p-S112,S115-SPRY2 [cytosol] (R-HSA-1295619) p-Y55,Y227-SPRY2 [plasma membrane] (R-HSA-934555) p-S112,S121-SPRY2 [plasma membrane] (R-HSA-934595) p-Y55,Y227-SPRY2 [plasma membrane] (R-HSA-1295629)	0.556	3