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GP9 [plasma membrane]
Stable Identifier
R-HSA-55881
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Platelet glycoprotein IX precursor, GPIX, CD42A
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of hemostasis (Homo sapiens)
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) (Homo sapiens)
Defective factor IX causes hemophilia B (Homo sapiens)
Defective F9 activation (Homo sapiens)
FIX(29-461) variant is not activated (factor XIa catalyst) (Homo sapiens)
factor XIa:GPIb:GPIX:GPV complex [plasma membrane] (Homo sapiens)
GPIb-IX-V [plasma membrane] (Homo sapiens)
GP9 [plasma membrane] (Homo sapiens)
Defects of platelet adhesion to exposed collagen (Homo sapiens)
Defective binding of VWF variant to GPIb:IX:V (Homo sapiens)
VWF variant does not bind GPIb:IX:V (Homo sapiens)
GP1BA:GP1BB:GP9:GP5 [plasma membrane] (Homo sapiens)
GP1BA:GP1BB:GP9 [plasma membrane] (Homo sapiens)
GP9 [plasma membrane] (Homo sapiens)
Enhanced binding of GP1BA variant to VWF multimer:collagen (Homo sapiens)
GP1BA variant binds to VWF multimer:collagen (Homo sapiens)
Collagen type I fibril:VWF multimer:GP1BA variant:GP1BB:GP9:GP5 [plasma membrane] (Homo sapiens)
GP1BA variant:GP1BB:GP9:GP5 [plasma membrane] (Homo sapiens)
GP1BA variant:GP1BB:GP9 [plasma membrane] (Homo sapiens)
GP9 [plasma membrane] (Homo sapiens)
GP1BA variant:GP1BB:GP9:GP5 [plasma membrane] (Homo sapiens)
GP1BA variant:GP1BB:GP9 [plasma membrane] (Homo sapiens)
GP9 [plasma membrane] (Homo sapiens)
Hemostasis (Homo sapiens)
Formation of Fibrin Clot (Clotting Cascade) (Homo sapiens)
Intrinsic Pathway of Fibrin Clot Formation (Homo sapiens)
factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst) (Homo sapiens)
factor XIa:GPIb:GPIX:GPV complex [plasma membrane] (Homo sapiens)
GPIb-IX-V [plasma membrane] (Homo sapiens)
GP9 [plasma membrane] (Homo sapiens)
factor XI + platelet glycoprotein (GP) Ib:IX:V complex -> factor XI:platelet glycoprotein (GP) Ib:IX:V complex (Homo sapiens)
GPIb-IX-V [plasma membrane] (Homo sapiens)
GP9 [plasma membrane] (Homo sapiens)
factor XI:GPIb-IX-V complex [plasma membrane] (Homo sapiens)
GPIb-IX-V [plasma membrane] (Homo sapiens)
GP9 [plasma membrane] (Homo sapiens)
factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (XIIa catalyst) (Homo sapiens)
factor XI:GPIb-IX-V complex [plasma membrane] (Homo sapiens)
GPIb-IX-V [plasma membrane] (Homo sapiens)
GP9 [plasma membrane] (Homo sapiens)
factor XIa:GPIb:GPIX:GPV complex [plasma membrane] (Homo sapiens)
GPIb-IX-V [plasma membrane] (Homo sapiens)
GP9 [plasma membrane] (Homo sapiens)
factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst) (Homo sapiens)
factor XI:GPIb-IX-V complex [plasma membrane] (Homo sapiens)
GPIb-IX-V [plasma membrane] (Homo sapiens)
GP9 [plasma membrane] (Homo sapiens)
factor XIa:GPIb:GPIX:GPV complex [plasma membrane] (Homo sapiens)
GPIb-IX-V [plasma membrane] (Homo sapiens)
GP9 [plasma membrane] (Homo sapiens)
Platelet Adhesion to exposed collagen (Homo sapiens)
GPIb:IX:V binds to VWF multimer:collagen (Homo sapiens)
GP1BA:GP1BB:GP9:GP5 [plasma membrane] (Homo sapiens)
GP1BA:GP1BB:GP9 [plasma membrane] (Homo sapiens)
GP9 [plasma membrane] (Homo sapiens)
GP1BA:GP1BB:GP9:GP5:VWF:collagen type I [plasma membrane] (Homo sapiens)
GP1BA:GP1BB:GP9:GP5 [plasma membrane] (Homo sapiens)
GP1BA:GP1BB:GP9 [plasma membrane] (Homo sapiens)
GP9 [plasma membrane] (Homo sapiens)
Platelet activation, signaling and aggregation (Homo sapiens)
GP1b-IX-V activation signalling (Homo sapiens)
GP1b signaling involves c-Src (Homo sapiens)
GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Homo sapiens)
GPIb-IX-V [plasma membrane] (Homo sapiens)
GP9 [plasma membrane] (Homo sapiens)
GP1b-IX-V binds 14-3-3-zeta (Homo sapiens)
GPIb-IX-V:Collagen type I fibril:vWF:14-3-3-zeta [plasma membrane] (Homo sapiens)
GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Homo sapiens)
GPIb-IX-V [plasma membrane] (Homo sapiens)
GP9 [plasma membrane] (Homo sapiens)
GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Homo sapiens)
GPIb-IX-V [plasma membrane] (Homo sapiens)
GP9 [plasma membrane] (Homo sapiens)
GP1b-IX-V binds filamin (Homo sapiens)
GPIb-IX-V:vWF:filamin-A [plasma membrane] (Homo sapiens)
GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Homo sapiens)
GPIb-IX-V [plasma membrane] (Homo sapiens)
GP9 [plasma membrane] (Homo sapiens)
GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Homo sapiens)
GPIb-IX-V [plasma membrane] (Homo sapiens)
GP9 [plasma membrane] (Homo sapiens)
GP1b-IX-V:13-3-3-zeta complexes with p85 PI3K (Homo sapiens)
GPIb-IX-V:Collagen type I fibril:vWF:14-3-3-zeta [plasma membrane] (Homo sapiens)
GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Homo sapiens)
GPIb-IX-V [plasma membrane] (Homo sapiens)
GP9 [plasma membrane] (Homo sapiens)
GPIb-IX-V:vWF:14-3-3-zeta:p85 [plasma membrane] (Homo sapiens)
GPIb-IX-V:Collagen type I fibril:vWF:14-3-3-zeta [plasma membrane] (Homo sapiens)
GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Homo sapiens)
GPIb-IX-V [plasma membrane] (Homo sapiens)
GP9 [plasma membrane] (Homo sapiens)
GPIb-IX-V binding to 14-3-3 zeta is reduced by shear stress (Homo sapiens)
GPIb-IX-V:Collagen type I fibril:vWF:14-3-3-zeta [plasma membrane] (Homo sapiens)
GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Homo sapiens)
GPIb-IX-V [plasma membrane] (Homo sapiens)
GP9 [plasma membrane] (Homo sapiens)
GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Homo sapiens)
GPIb-IX-V [plasma membrane] (Homo sapiens)
GP9 [plasma membrane] (Homo sapiens)
GPIb-IX-V binds to vWF:Collagen complex (Homo sapiens)
GPIb-IX-V [plasma membrane] (Homo sapiens)
GP9 [plasma membrane] (Homo sapiens)
GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Homo sapiens)
GPIb-IX-V [plasma membrane] (Homo sapiens)
GP9 [plasma membrane] (Homo sapiens)
Platelet Aggregation (Plug Formation) (Homo sapiens)
Thrombin binding to GP1b:IX:V (Homo sapiens)
GP1b-IX-V complex:activated thrombin (factor IIa) [plasma membrane] (Homo sapiens)
GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Homo sapiens)
GPIb-IX-V [plasma membrane] (Homo sapiens)
GP9 [plasma membrane] (Homo sapiens)
GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Homo sapiens)
GPIb-IX-V [plasma membrane] (Homo sapiens)
GP9 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P14770 GP9
Gene Names
GP9
Chain
signal peptide:1-16, chain:17-177
Reference Genes
BioGPS Gene:2815 GP9
COSMIC (genes):GP9 GP9
CTD Gene:2815 GP9
dbSNP Gene:2815 GP9
ENSEMBL:ENSG00000169704 GP9
HGNC:4444 GP9
KEGG:hsa:2815 GP9
Monarch:2815 GP9
NCBI Gene:2815 GP9
OMIM:173515 GP9
UCSC:P14770 GP9
Reference Transcript
RefSeq:XM_005247374.3 GP9
RefSeq:NM_000174.4 GP9
RefSeq:XM_011512701.1 GP9
RefSeq:XM_011512702.1 GP9
Other Identifiers
11730648_at
16945305
206883_PM_x_at
206883_x_at
2641480
2641482
2641484
2641485
2641486
2815
35101_at
8082473
A_23_P33256
A_33_P3383226
GE533113
GO:0005515
GO:0005886
GO:0007155
GO:0007596
GO:0007597
GO:0010572
GO:0016020
GO:0035855
GO:0048856
GO:0051209
GO:0051604
GO:0055085
GO:1990779
HMNXSV003020033
ILMN_1743290
M80478_at
TC03000686.hg
g4504076_3p_at
Participates
as a component of
GP1BA variant:GP1BB:GP9 [plasma membrane] (Homo sapiens)
GP1BA:GP1BB:GP9 [plasma membrane] (Homo sapiens)
GPIb-IX-V [plasma membrane] (Homo sapiens)
Inferred To
Ghost homologue of GP9 [plasma membrane]
(Danio rerio)
LOC116410485 [plasma membrane]
(Xenopus tropicalis)
GP9 [plasma membrane]
(Bos taurus)
GP9 [plasma membrane]
(Gallus gallus)
GP9 [plasma membrane]
(Sus scrofa)
Gp9 [plasma membrane]
(Mus musculus)
Gp9 [plasma membrane]
(Rattus norvegicus)
Cross References
RefSeq
XP_011511003.1
,
XP_011511004.1
,
XP_005247431.1
,
NP_000165.1
ENSEMBL
ENSP00000303942
,
ENST00000307395
OpenTargets
ENSG00000169704
HPA
ENSG00000169704-GP9
PRO
P14770
Pharos - Targets
P14770
GlyGen
P14770
Orphanet
GP9
PDB
3REZ
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P07359 GP1BA
6
GP1BA [plasma membrane]
(R-HSA-55861)
GP1BA D251Y [plasma membrane]
(R-HSA-9844197)
GP1BA W246L [plasma membrane]
(R-HSA-9844258)
GP1BA M255V [plasma membrane]
(R-HSA-9844240)
GP1BA G249V [plasma membrane]
(R-HSA-9844257)
GP1BA G249S [plasma membrane]
(R-HSA-9844280)
0.787
7
UniProt:P49639 HOXA1
1
HOXA1 [nucleoplasm]
(R-HSA-5617464)
0.666
4
UniProt:O43597 SPRY2
8
p-S112,S115-SPRY2 [cytosol]
(R-HSA-1295619)
SPRY2 [cytosol]
(R-HSA-182949)
SPRY2 [plasma membrane]
(R-HSA-182924)
p-S112,S121-SPRY2 [plasma membrane]
(R-HSA-934595)
p-Y55,Y227-SPRY2 [plasma membrane]
(R-HSA-934555)
p-S111,S120-SPRY2 [cytosol]
(R-HSA-1295590)
p-Y55,Y227-SPRY2 [plasma membrane]
(R-HSA-1295629)
p-Y55-SPRY2 [cytosol]
(R-HSA-182950)
0.556
3
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