TNRC6A binds AGO2:miRNA

Stable Identifier
Reaction [binding]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
TNRC6A (GW182) is a major component of miRISC and processing bodies (P bodies or GW bodies) where transcripts are degraded (Eystathioy et al. 2003). GW182 posesses several glycine-tryptophan (GW) repeats that enable interactions with Argonaute proteins (Eulalio et al. 2009, Takimoto et al. 2009). Humans express three paralogs (TNRC6A, TNRC6B, and TNRC6C) which can each silence expression of mRNAs to which they are bound (Lazzaretti et al. 2009). In the cytosol TNRC6A binds AGO2:miRNA via three GW-repeat motifs (Landthaler et al. 2008, Takimoto et al. 2009, Nishi et al. 2013).
Literature References
PubMed ID Title Journal Year
18978028 Molecular characterization of human Argonaute-containing ribonucleoprotein complexes and their bound target mRNAs

Ojo, T, Landthaler, M, Hafner, M, Tuschl, T, Soll, SJ, Zavolan, M, Gaidatzis, D, Dinic, L, Rothballer, A, Chen, PY

RNA 2008
19383768 The C-terminal domains of human TNRC6A, TNRC6B, and TNRC6C silence bound transcripts independently of Argonaute proteins

Lazzaretti, D, Tournier, I, Izaurralde, E

RNA 2009
19383769 A C-terminal silencing domain in GW182 is essential for miRNA function

Fritzsch, C, Eulalio, A, Fauser, M, Izaurralde, E, Helms, S

RNA 2009
13130130 The GW182 protein colocalizes with mRNA degradation associated proteins hDcp1 and hLSm4 in cytoplasmic GW bodies

Séraphin, B, Eystathioy, T, Cougot, N, Fritzler, MJ, Chan, EK, Jakymiw, A

RNA 2003
19398495 Mammalian GW182 contains multiple Argonaute-binding sites and functions in microRNA-mediated translational repression

Wakiyama, M, Takimoto, K, Yokoyama, S

RNA 2009
23150874 Human TNRC6A is an Argonaute-navigator protein for microRNA-mediated gene silencing in the nucleus

Nishi, A, Nishi, K, Nagasawa, T, Ui-Tei, K

RNA 2013
Orthologous Events
Cite Us!