Reactome | TNRC6A binds AGO2:miRNA

TNRC6A binds AGO2:miRNA

Stable Identifier

R-HSA-5578965

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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TNRC6A (GW182) is a major component of miRISC and processing bodies (P bodies or GW bodies) where transcripts are degraded (Eystathioy et al. 2003). GW182 posesses several glycine-tryptophan (GW) repeats that enable interactions with Argonaute proteins (Eulalio et al. 2009, Takimoto et al. 2009). Humans express three paralogs (TNRC6A, TNRC6B, and TNRC6C) which can each silence expression of mRNAs to which they are bound (Lazzaretti et al. 2009). In the cytosol TNRC6A binds AGO2:miRNA via three GW-repeat motifs (Landthaler et al. 2008, Takimoto et al. 2009, Nishi et al. 2013).

Literature References

PubMed ID	Title	Journal	Year
18978028	Molecular characterization of human Argonaute-containing ribonucleoprotein complexes and their bound target mRNAs Landthaler, M, Gaidatzis, D, Rothballer, A, Chen, PY, Soll, SJ, Dinic, L, Ojo, T, Hafner, M, Zavolan, M, Tuschl, T	RNA	2008
19383768	The C-terminal domains of human TNRC6A, TNRC6B, and TNRC6C silence bound transcripts independently of Argonaute proteins Lazzaretti, D, Tournier, I, Izaurralde, E	RNA	2009
19383769	A C-terminal silencing domain in GW182 is essential for miRNA function Eulalio, A, Helms, S, Fritzsch, C, Fauser, M, Izaurralde, E	RNA	2009
13130130	The GW182 protein colocalizes with mRNA degradation associated proteins hDcp1 and hLSm4 in cytoplasmic GW bodies Eystathioy, T, Jakymiw, A, Chan, EK, Séraphin, B, Cougot, N, Fritzler, MJ	RNA	2003
19398495	Mammalian GW182 contains multiple Argonaute-binding sites and functions in microRNA-mediated translational repression Takimoto, K, Wakiyama, M, Yokoyama, S	RNA	2009
23150874	Human TNRC6A is an Argonaute-navigator protein for microRNA-mediated gene silencing in the nucleus Nishi, K, Nishi, A, Nagasawa, T, Ui-Tei, K	RNA	2013