CORIN(802-1042) hydrolyses NPPA to form NPPA(124-151)

Stable Identifier
R-HSA-5578783
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
CORIN(802-1042) hydrolyses natriuretic peptides A (NPPA) to form atrial natriuretic factor (ANF)
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Atrial natriuretic factor (NPPA(124-151) aka ANF) is a cardiac hormone essential for the regulation of blood pressure and promoting natriuresis, diuresis and vasodilation. In cardiac myocytes, NPPA is synthesised as an inactive precursor, pro-NPPA, that is converted to the biologically-active form by cleavage. Atrial natriuretic peptide-converting enzyme (CORIN) is the serine-type endopeptidase involved in NPPA processing. It is itself cleaved into 5 chains, with CORIN(802-1042) being the activated protease fragment (Yan et al. 2000, Knappe et al. 2003, Liao et al. 2007).

Literature References
PubMed ID Title Journal Year
10880574 Corin, a transmembrane cardiac serine protease, acts as a pro-atrial natriuretic peptide-converting enzyme

Yan, W, Wu, F, Morser, J, Wu, Q

Proc. Natl. Acad. Sci. U.S.A. 2000
17660514 Role of glycosylation in corin zymogen activation

Liao, X, Wang, W, Chen, S, Wu, Q

J. Biol. Chem. 2007
14559895 Functional analysis of the transmembrane domain and activation cleavage of human corin: design and characterization of a soluble corin

Knappe, S, Wu, F, Masikat, MR, Morser, J, Wu, Q

J. Biol. Chem. 2003
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
serine-type endopeptidase activity of CORIN(802-1042) [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created