CORIN(802-1042) hydrolyses NPPA to form NPPA(124-151)

Stable Identifier
Reaction [transition]
Homo sapiens
CORIN(802-1042) hydrolyses natriuretic peptides A (NPPA) to form atrial natriuretic factor (ANF)
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Atrial natriuretic factor (NPPA(124-151) aka ANF) is a cardiac hormone essential for the regulation of blood pressure and promoting natriuresis, diuresis and vasodilation. In cardiac myocytes, NPPA is synthesised as an inactive precursor, pro-NPPA, that is converted to the biologically-active form by cleavage. Atrial natriuretic peptide-converting enzyme (CORIN) is the serine-type endopeptidase involved in NPPA processing. It is itself cleaved into 5 chains, with CORIN(802-1042) being the activated protease fragment (Yan et al. 2000, Knappe et al. 2003, Liao et al. 2007).

Literature References
PubMed ID Title Journal Year
17660514 Role of glycosylation in corin zymogen activation

Chen, S, Liao, X, Wu, Q, Wang, W

J. Biol. Chem. 2007
10880574 Corin, a transmembrane cardiac serine protease, acts as a pro-atrial natriuretic peptide-converting enzyme

Morser, J, Yan, W, Wu, F, Wu, Q

Proc. Natl. Acad. Sci. U.S.A. 2000
14559895 Functional analysis of the transmembrane domain and activation cleavage of human corin: design and characterization of a soluble corin

Knappe, S, Wu, F, Wu, Q, Masikat, MR, Morser, J

J. Biol. Chem. 2003
Catalyst Activity

serine-type endopeptidase activity of CORIN(802-1042) [plasma membrane]

Orthologous Events
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