Two potassium currents, IKs and IKr, provide the principal repolarising currents in cardiac myocytes for the termination of action potentials. The potassium voltage-gated channel subfamily H member 2 (KCNH2 aka HERG) is the pore-forming alpha subunit of a stable complex with a regulating beta subunit of the potassium voltage-gated channel subfamily E family (KCNE). This stable complex creates the Kr current by the efflux of K+ (Macdonald et al. 1997, Abbott et al. 1999).
Palma, E, Fishman, GI, Ming, Z, Goldstein, SA, Yu, Z, Meyers, MB, McDonald, TV, Wang, KW
Abbott, GW, Keating, MT, Timothy, KW, Buck, ME, Sesti, F, Goldstein, SA, Lehmann, MH, Splawski, I
delayed rectifier potassium channel activity of KCNH2:KCNE [plasma membrane]
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