KCNH2:KCNE transport K+ from cytosol to extracellular region

Stable Identifier
R-HSA-5577237
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Two potassium currents, IKs and IKr, provide the principal repolarising currents in cardiac myocytes for the termination of action potentials. The potassium voltage-gated channel subfamily H member 2 (KCNH2 aka HERG) is the pore-forming alpha subunit of a stable complex with a regulating beta subunit of the potassium voltage-gated channel subfamily E family (KCNE). This stable complex creates the Kr current by the efflux of K+ (Macdonald et al. 1997, Abbott et al. 1999).

Literature References
PubMed ID Title Journal Year
10219239 MiRP1 forms IKr potassium channels with HERG and is associated with cardiac arrhythmia

Abbott, GW, Sesti, F, Splawski, I, Buck, ME, Lehmann, MH, Timothy, KW, Keating, MT, Goldstein, SA

Cell 1999
9230439 A minK-HERG complex regulates the cardiac potassium current I(Kr)

McDonald, TV, Yu, Z, Ming, Z, Palma, E, Meyers, MB, Wang, KW, Goldstein, SA, Fishman, GI

Nature 1997
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Participant Of
Catalyst Activity
Catalyst Activity
Title
delayed rectifier potassium channel activity of KCNH2:KCNE [plasma membrane]
Physical Entity
Activity
This event is regulated
Orthologous Events
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