Phase 1 - inactivation of fast Na+ channels

Stable Identifier
R-HSA-5576894
Type
Pathway
Species
Homo sapiens
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Phase 1 - inactivation of fast Na+ channels
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Phase 1 of the cardiac action potential is the inactivation of the fast Na+ channels. The transient net outward current causing the small downward deflection (the "notch" of the action potetial) is due to the movement of K+ and Cl- ions. In pacemaker cells, this phase is due to rapid K+ efflux and closure of L-type Ca2+ channels (Park & Fishman 2011, Grant 2009).

Literature References
PubMed ID Title Journal Year
21357845 The cardiac conduction system

Park, DS, Fishman, GI

Circulation 2011
19808464 Cardiac ion channels

Grant, AO

Circ Arrhythm Electrophysiol 2009
Participants
Events
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as an event of
Event Information
Go Biological Process
cardiac conduction (0061337)
Orthologous Events
Phase 1 - inactivation of fast Na+ channels (Bos taurus)
Phase 1 - inactivation of fast Na+ channels (Caenorhabditis elegans)
Phase 1 - inactivation of fast Na+ channels (Canis familiaris)
Phase 1 - inactivation of fast Na+ channels (Danio rerio)
Phase 1 - inactivation of fast Na+ channels (Drosophila melanogaster)
Phase 1 - inactivation of fast Na+ channels (Gallus gallus)
Phase 1 - inactivation of fast Na+ channels (Mus musculus)
Phase 1 - inactivation of fast Na+ channels (Rattus norvegicus)
Phase 1 - inactivation of fast Na+ channels (Sus scrofa)
Phase 1 - inactivation of fast Na+ channels (Xenopus tropicalis)
Authored
Jassal, B  (2014-05-27)
Reviewed
Colotti, G  (2015-11-09)
Created
Jassal, B  (2014-05-27)
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