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Phase 1 - inactivation of fast Na+ channels
Stable Identifier
R-HSA-5576894
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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Muscle contraction (Homo sapiens)
Cardiac conduction (Homo sapiens)
Phase 1 - inactivation of fast Na+ channels (Homo sapiens)
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Phase 1 of the cardiac action potential is the inactivation of the fast Na+ channels. The transient net outward current causing the small downward deflection (the "notch" of the action potetial) is due to the movement of K+ and Cl- ions. In pacemaker cells, this phase is due to rapid K+ efflux and closure of L-type Ca2+ channels (Park & Fishman 2011, Grant 2009).
Literature References
PubMed ID
Title
Journal
Year
21357845
The cardiac conduction system
Park, DS
,
Fishman, GI
Circulation
2011
19808464
Cardiac ion channels
Grant, AO
Circ Arrhythm Electrophysiol
2009
Participants
Events
KCND tetramer:KCNIP tetramer transport K+ from cytosol to extracellular region
(Homo sapiens)
Participates
as an event of
Cardiac conduction (Homo sapiens)
Event Information
Go Biological Process
cardiac conduction (0061337)
Orthologous Events
Phase 1 - inactivation of fast Na+ channels (Bos taurus)
Phase 1 - inactivation of fast Na+ channels (Caenorhabditis elegans)
Phase 1 - inactivation of fast Na+ channels (Canis familiaris)
Phase 1 - inactivation of fast Na+ channels (Danio rerio)
Phase 1 - inactivation of fast Na+ channels (Drosophila melanogaster)
Phase 1 - inactivation of fast Na+ channels (Gallus gallus)
Phase 1 - inactivation of fast Na+ channels (Mus musculus)
Phase 1 - inactivation of fast Na+ channels (Rattus norvegicus)
Phase 1 - inactivation of fast Na+ channels (Sus scrofa)
Phase 1 - inactivation of fast Na+ channels (Xenopus tropicalis)
Authored
Jassal, B (2014-05-27)
Reviewed
Colotti, G (2015-11-09)
Created
Jassal, B (2014-05-27)
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