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ub-SHH processing variants:OS9/ERLEC1 [endoplasmic reticulum lumen]
Stable Identifier
R-HSA-5483237
Type
Complex
Species
Homo sapiens
Compartment
endoplasmic reticulum lumen
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Hh mutants abrogate ligand secretion (Homo sapiens)
Hh mutants that don't undergo autocatalytic processing are degraded by ERAD (Homo sapiens)
Hh processing variants are translocated to the cytosol in a VCP-dependent manner (Homo sapiens)
ub-SHH processing variants:ERLEC:OS9:SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Homo sapiens)
ub-SHH processing variants:OS9/ERLEC1 [endoplasmic reticulum lumen] (Homo sapiens)
Hh processing variants are ubiquitinated (Homo sapiens)
ub-SHH processing variants:ERLEC:OS9:SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Homo sapiens)
ub-SHH processing variants:OS9/ERLEC1 [endoplasmic reticulum lumen] (Homo sapiens)
Participants
components
OS9/ERLEC1 [endoplasmic reticulum quality control compartment] (Homo sapiens)
ub SHH mutants [endoplasmic reticulum lumen] (Homo sapiens)
Participant Of
hasComponent
ub-SHH processing variants:ERLEC:OS9:SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane]
Disease
Name
Identifier
Synonyms
holoprosencephaly
4621
Holoprosencephaly sequence (disorder)
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