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MTRF1 [mitochondrial matrix]
Stable Identifier
R-HSA-5432599
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
mitochondrial matrix
Synonyms
Peptide chain release factor 1, mitochondrial, RF1M_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Translation (Homo sapiens)
Mitochondrial translation (Homo sapiens)
Mitochondrial translation termination (Homo sapiens)
55S ribosome:MTRF1 hydrolyzes peptidyl-tRNA bond and GTP is hydrolyzed (Homo sapiens)
55S ribosome:MT-CO1,MT-ND6 mRNA:peptidyl-tRNA:tRNA:MTRF1:GTP [mitochondrial inner membrane] (Homo sapiens)
MTRF1 [mitochondrial matrix] (Homo sapiens)
MTRF1 [mitochondrial matrix] (Homo sapiens)
MTRF1 and GTP bind 55S ribosome:MT-CO1,MT-ND6 mRNA:peptidyl-tRNA at P-site:tRNA at E-site (Homo sapiens)
55S ribosome:MT-CO1,MT-ND6 mRNA:peptidyl-tRNA:tRNA:MTRF1:GTP [mitochondrial inner membrane] (Homo sapiens)
MTRF1 [mitochondrial matrix] (Homo sapiens)
MTRF1 [mitochondrial matrix] (Homo sapiens)
External Reference Information
External Reference
UniProt:O75570 MTRF1
Gene Names
MTRF1
Chain
transit peptide:1-61, chain:62-445
Reference Genes
BioGPS Gene:9617 MTRF1
COSMIC - genes:MTRF1 MTRF1
CTD Gene:9617 MTRF1
dbSNP Gene:9617 MTRF1
ENSEMBL:ENSG00000120662 MTRF1
HGNC:7469 MTRF1
KEGG:hsa:9617 MTRF1
Monarch:9617 MTRF1
NCBI Gene:9617 MTRF1
OMIM:604601 MTRF1
UCSC:O75570 MTRF1
Reference Transcript
RefSeq:XM_047430797.1 MTRF1
RefSeq:XM_047430795.1 MTRF1
RefSeq:XM_047430796.1 MTRF1
RefSeq:XM_047430794.1 MTRF1
RefSeq:XM_054375219.1 MTRF1
RefSeq:XM_054375215.1 MTRF1
RefSeq:XM_054375216.1 MTRF1
RefSeq:NM_001354074.1 MTRF1
RefSeq:XM_054375221.1 MTRF1
RefSeq:XM_047430791.1 MTRF1
RefSeq:XM_054375213.1 MTRF1
RefSeq:XM_024449440.2 MTRF1
RefSeq:XM_054375214.1 MTRF1
RefSeq:XM_024449442.2 MTRF1
RefSeq:XM_017020866.3 MTRF1
RefSeq:XM_054375218.1 MTRF1
RefSeq:XM_047430790.1 MTRF1
RefSeq:XM_047430793.1 MTRF1
RefSeq:XM_047430792.1 MTRF1
RefSeq:NM_001354073.1 MTRF1
RefSeq:XM_047430798.1 MTRF1
RefSeq:XM_024449441.2 MTRF1
RefSeq:NM_001354076.1 MTRF1
RefSeq:XM_047430789.1 MTRF1
RefSeq:XM_054375217.1 MTRF1
RefSeq:NM_004294.2 MTRF1
Other Identifiers
11732872_a_at
11732873_x_at
11747009_a_at
11752755_a_at
16778468
219822_PM_at
219822_at
242996_PM_at
242996_at
244763_PM_at
244763_at
3511190
3511191
3511192
3511193
3511194
3511196
3511198
3511199
3511201
3511203
3511204
3511205
3511206
3511208
3511209
3511210
3511211
3511212
3511213
3511214
3511215
3511216
3511217
3511218
3511219
3511220
3511221
47081_at
7971222
92053_at
9617
A_23_P37005
A_24_P349821
GE54685
GO:0003747
GO:0005737
GO:0005739
GO:0006412
GO:0006415
GO:0016149
GO:0070126
HMNXSV003010044
Hs.171515.0.A1_3p_at
Hs.246268.0.A1_3p_at
ILMN_2181992
PH_hs_0023913
PH_hs_0032762
TC13000602.hg
TC13000603.hg
g4758743_3p_at
Participates
as an input of
MTRF1 and GTP bind 55S ribosome:MT-CO1,MT-ND6 mRNA:peptidyl-tRNA at P-site:tRNA at E-site (Homo sapiens)
as an output of
55S ribosome:MTRF1 hydrolyzes peptidyl-tRNA bond and GTP is hydrolyzed (Homo sapiens)
as a component of
55S ribosome:MT-CO1,MT-ND6 mRNA:peptidyl-tRNA:tRNA:MTRF1:GTP [mitochondrial inner membrane] (Homo sapiens)
Inferred To
mRF1 [mitochondrial matrix]
(Drosophila melanogaster)
mtrf-1L [mitochondrial matrix]
(Caenorhabditis elegans)
Ghost homologue of MTRF1 [mitochondrial matrix]
(Danio rerio)
Ghost homologue of MTRF1 [mitochondrial matrix]
(Xenopus tropicalis)
MTRF1 [mitochondrial matrix]
(Bos taurus)
MTRF1 [mitochondrial matrix]
(Canis familiaris)
MTRF1 [mitochondrial matrix]
(Gallus gallus)
MTRF1 [mitochondrial matrix]
(Sus scrofa)
Mtrf1 [mitochondrial matrix]
(Mus musculus)
Mtrf1 [mitochondrial matrix]
(Rattus norvegicus)
Cross References
RefSeq
XP_054231190.1
,
XP_054231194.1
,
XP_054231196.1
,
XP_054231193.1
,
XP_054231191.1
,
XP_054231192.1
,
XP_047286746.1
,
XP_024305209.1
,
XP_024305208.1
,
XP_047286747.1
,
XP_024305210.1
,
XP_047286750.1
,
XP_047286751.1
,
XP_047286752.1
,
XP_054231189.1
,
XP_054231188.1
,
XP_047286754.1
,
XP_047286753.1
,
NP_001341002.1
,
NP_001341003.1
,
NP_001341005.1
,
XP_047286745.1
,
XP_047286748.1
,
XP_047286749.1
,
NP_004285.2
,
XP_016876355.1
OpenTargets
ENSG00000120662
ENSEMBL
ENSP00000368793
,
ENSP00000368790
,
ENST00000379480
,
ENSG00000120662
,
ENST00000379477
HPA
ENSG00000120662-MTRF1
GeneCards
MTRF1
PRO
O75570
Pharos - Targets
O75570
PDB
8OIS
,
8OIR
,
8OIT
,
8OIN
,
8OIP
,
8OIQ
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