Reactome | EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha)

EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha)

Stable Identifier

R-HSA-5358597

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

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EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha)

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EXO1 interacts with MSH2 and MLH1 (and therefore is presumed to interact with their respective heterodimers MSH2:MSH6 and MLH1:PMS2), forming a ternary complex with MLH1:PMS2 (Nielsen et al. 2004). EXO1 also interacts with PCNA in S phase (Nielsen et al. 2004, Zhang et al. 2005, Constantin et al. 2005, Knudsen et al. 2007, Liberti et al. 2011)

Literature References

PubMed ID	Title	Journal	Year
16143102	Reconstitution of 5'-directed human mismatch repair in a purified system Zhang, Y, Yuan, F, Presnell, SR, Tian, K, Gao, Y, Tomkinson, AE, Gu, L, Li, GM	Cell	2005
20970388	Bi-directional routing of DNA mismatch repair protein human exonuclease 1 to replication foci and DNA double strand breaks Liberti, SE, Andersen, SD, Wang, J, May, A, Miron, S, Perderiset, M, Keijzers, G, Nielsen, FC, Charbonnier, JB, Bohr, VA, Rasmussen, LJ	DNA Repair (Amst.)	2011
14676842	Characterization of human exonuclease 1 in complex with mismatch repair proteins, subcellular localization and association with PCNA Nielsen, FC, Jäger, AC, Lützen, A, Bundgaard, JR, Rasmussen, LJ	Oncogene	2004
17426132	Nuclear localization of human DNA mismatch repair protein exonuclease 1 (hEXO1) Knudsen, NØ, Nielsen, FC, Vinther, L, Bertelsen, R, Holten-Andersen, S, Liberti, SE, Hofstra, R, Kooi, K, Rasmussen, LJ	Nucleic Acids Res.	2007
16188885	Human mismatch repair: reconstitution of a nick-directed bidirectional reaction Constantin, N, Dzantiev, L, Kadyrov, FA, Modrich, P	J. Biol. Chem.	2005