EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha)

Stable Identifier
Reaction [binding]
Homo sapiens
Locations in the PathwayBrowser
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EXO1 interacts with MSH2 and MLH1 (and therefore is presumed to interact with their respective heterodimers MSH2:MSH6 and MLH1:PMS2), forming a ternary complex with MLH1:PMS2 (Nielsen et al. 2004). EXO1 also interacts with PCNA in S phase (Nielsen et al. 2004, Zhang et al. 2005, Constantin et al. 2005, Knudsen et al. 2007, Liberti et al. 2011)
Literature References
PubMed ID Title Journal Year
20970388 Bi-directional routing of DNA mismatch repair protein human exonuclease 1 to replication foci and DNA double strand breaks

Rasmussen, LJ, Miron, S, May, A, Bohr, VA, Liberti, SE, Wang, J, Charbonnier, JB, Andersen, SD, Keijzers, G, Nielsen, FC, Perderiset, M

DNA Repair (Amst.) 2011
16143102 Reconstitution of 5'-directed human mismatch repair in a purified system

Gao, Y, Zhang, Y, Li, GM, Yuan, F, Tian, K, Presnell, SR, Gu, L, Tomkinson, AE

Cell 2005
14676842 Characterization of human exonuclease 1 in complex with mismatch repair proteins, subcellular localization and association with PCNA

Rasmussen, LJ, Lützen, A, Nielsen, FC, Bundgaard, JR, Jäger, AC

Oncogene 2004
17426132 Nuclear localization of human DNA mismatch repair protein exonuclease 1 (hEXO1)

Kooi, K, Liberti, SE, Rasmussen, LJ, Bertelsen, R, Knudsen, NØ, Nielsen, FC, Holten-Andersen, S, Hofstra, R, Vinther, L

Nucleic Acids Res. 2007
16188885 Human mismatch repair: reconstitution of a nick-directed bidirectional reaction

Dzantiev, L, Modrich, P, Kadyrov, FA, Constantin, N

J. Biol. Chem. 2005
Orthologous Events
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