MSH2:MSH3 binds insertion/deletion loop of 2 bases or more

Stable Identifier
Reaction [binding]
Homo sapiens
MutSbeta binds insertion/deletion loop of 2 bases or more
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MSH2:MSH3 (MutSbeta) binds preferentially to insertions and deletion loops (IDLs) of 2 bases or more (Palombo et al. 1996, Drummond et al. 1997, Genschel et al. 1998, Tian et al. 2009, Panigrahi et al. 2010, Kantelinen et al. 2010, Gupta et al. 2012). Unlike MSH2:MSH6 (MutSalpha), which binds the base of a mismatched nucleotide, MSH2:MSH3 binds 3 phosphates in the loop of unpaired nucleotides (Gupta et al. 2012). MSH2:MSH3 is localized at replication foci during S phase via an interaction between MSH3 and PCNA (Kleczkowska et al. 2001).
Literature References
PubMed ID Title Journal Year
11274057 hMSH3 and hMSH6 interact with PCNA and colocalize with it to replication foci

Jiricny, J, Marra, G, Lettieri, T, Kleczkowska, HE

Genes Dev. 2001
19228687 Distinct nucleotide binding/hydrolysis properties and molar ratio of MutSalpha and MutSbeta determine their differential mismatch binding activities

Li, GM, Tian, L, Gu, L

J. Biol. Chem. 2009
22179786 Mechanism of mismatch recognition revealed by human MutS? bound to unpaired DNA loops

Gupta, S, Gellert, M, Yang, W

Nat. Struct. Mol. Biol. 2012
8805365 hMutSbeta, a heterodimer of hMSH2 and hMSH3, binds to insertion/deletion loops in DNA

Jiricny, J, Iaccarino, I, Palombo, F, Shimada, T, Nakajima, E, Ikejima, M

Curr. Biol. 1996
20160730 MutSbeta exceeds MutSalpha in dinucleotide loop repair

Kariola, R, Korhonen, MK, Kantelinen, J, Nyström, M, Kansikas, M, Heinimann, K, Ollila, S

Br. J. Cancer 2010
9677427 Isolation of MutSbeta from human cells and comparison of the mismatch repair specificities of MutSbeta and MutSalpha

Drummond, JT, Littman, SJ, Genschel, J, Modrich, P

J. Biol. Chem. 1998
20571119 Isolated short CTG/CAG DNA slip-outs are repaired efficiently by hMutSbeta, but clustered slip-outs are poorly repaired

Gileadi, O, Pearson, CE, Simard, JP, Slean, MM, Panigrahi, GB

Proc. Natl. Acad. Sci. U.S.A. 2010
9294177 DHFR/MSH3 amplification in methotrexate-resistant cells alters the hMutSalpha/hMutSbeta ratio and reduces the efficiency of base-base mismatch repair

Drummond, JT, Genschel, J, Wolf, E, Modrich, P

Proc. Natl. Acad. Sci. U.S.A. 1997
Orthologous Events
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