Reactome | MSH2:MSH3 binds insertion/deletion loop of 2 bases or more

MSH2:MSH3 binds insertion/deletion loop of 2 bases or more

Stable Identifier

R-HSA-5358513

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

MutSbeta binds insertion/deletion loop of 2 bases or more

ReviewStatus

5/5

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MSH2:MSH3 binds insertion/deletion loop of 2 bases or more

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MSH2:MSH3 (MutSbeta) binds preferentially to insertions and deletion loops (IDLs) of 2 bases or more (Palombo et al. 1996, Drummond et al. 1997, Genschel et al. 1998, Tian et al. 2009, Panigrahi et al. 2010, Kantelinen et al. 2010, Gupta et al. 2012). Unlike MSH2:MSH6 (MutSalpha), which binds the base of a mismatched nucleotide, MSH2:MSH3 binds 3 phosphates in the loop of unpaired nucleotides (Gupta et al. 2012). MSH2:MSH3 is localized at replication foci during S phase via an interaction between MSH3 and PCNA (Kleczkowska et al. 2001).

Literature References

PubMed ID	Title	Journal	Year
11274057	hMSH3 and hMSH6 interact with PCNA and colocalize with it to replication foci Kleczkowska, HE, Marra, G, Lettieri, T, Jiricny, J	Genes Dev.	2001
19228687	Distinct nucleotide binding/hydrolysis properties and molar ratio of MutSalpha and MutSbeta determine their differential mismatch binding activities Tian, L, Gu, L, Li, GM	J. Biol. Chem.	2009
22179786	Mechanism of mismatch recognition revealed by human MutS? bound to unpaired DNA loops Gupta, S, Gellert, M, Yang, W	Nat. Struct. Mol. Biol.	2012
8805365	hMutSbeta, a heterodimer of hMSH2 and hMSH3, binds to insertion/deletion loops in DNA Palombo, F, Iaccarino, I, Nakajima, E, Ikejima, M, Shimada, T, Jiricny, J	Curr. Biol.	1996
20160730	MutSbeta exceeds MutSalpha in dinucleotide loop repair Kantelinen, J, Kansikas, M, Korhonen, MK, Ollila, S, Heinimann, K, Kariola, R, Nyström, M	Br. J. Cancer	2010
9677427	Isolation of MutSbeta from human cells and comparison of the mismatch repair specificities of MutSbeta and MutSalpha Genschel, J, Littman, SJ, Drummond, JT, Modrich, P	J. Biol. Chem.	1998
20571119	Isolated short CTG/CAG DNA slip-outs are repaired efficiently by hMutSbeta, but clustered slip-outs are poorly repaired Panigrahi, GB, Slean, MM, Simard, JP, Gileadi, O, Pearson, CE	Proc. Natl. Acad. Sci. U.S.A.	2010
9294177	DHFR/MSH3 amplification in methotrexate-resistant cells alters the hMutSalpha/hMutSbeta ratio and reduces the efficiency of base-base mismatch repair Drummond, JT, Genschel, J, Wolf, E, Modrich, P	Proc. Natl. Acad. Sci. U.S.A.	1997