Polyubiquitinated RIP1 binds to TAB2 resulting in the recruitment of the TAB2:TAK1 complex. The K63-linked ubiqitination on Lys377 of RIP1 was reporeted to mediate the association of RIP with the TAB2:TAK1 complex (Li H et al. 2006)
Blonska, M, Shambharkar, PB, Kobayashi, M, Zhang, D, Sakurai, H, Su, B, Lin, X
Jackson-Bernitsas, DG, Ichikawa, H, Takada, Y, Myers, JN, Lin, XL, Darnay, BG, Chaturvedi, MM, Aggarwal, BB
© 2021 Reactome
