GPR37 binds prosaptide

Stable Identifier
R-HSA-5336182
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

GPR37 and GPR37L1 are almost exclusively expressed in the nervous system. They bind and are activated by the secreted neuroprotective and glioprotective factor prosaposin and a fragment of this named prosaptide. Signaling involves G-alpha-i/o.

Literature References
PubMed ID Title Journal Year
23690594 GPR37 and GPR37L1 are receptors for the neuroprotective and glioprotective factors prosaptide and prosaposin

Meyer, RC, Giddens, MM, Schaefer, SA, Hall, RA

Proc. Natl. Acad. Sci. U.S.A. 2013
Participants
Participant Of
Orthologous Events
Authored
Reviewed