GPR37 binds prosaptide

Stable Identifier
R-HSA-5336182
Type
Reaction
Species
Homo sapiens
Compartment
plasma membrane, extracellular region
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GPR37 binds prosaptide
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GPR37 and GPR37L1 are almost exclusively expressed in the nervous system. They bind and are activated by the secreted neuroprotective and glioprotective factor prosaposin and a fragment of this named prosaptide. Signaling involves G-alpha-i/o.

Literature References
PubMed ID Title Journal Year
23690594 GPR37 and GPR37L1 are receptors for the neuroprotective and glioprotective factors prosaptide and prosaposin

Hall, RA, Meyer, RC, Schaefer, SA, Giddens, MM

Proc. Natl. Acad. Sci. U.S.A. 2013
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Orthologous Events
GPR37 binds prosaptide (Canis familiaris)
GPR37 binds prosaptide (Danio rerio)
GPR37 binds prosaptide (Gallus gallus)
GPR37 binds prosaptide (Mus musculus)
GPR37 binds prosaptide (Rattus norvegicus)
Authored
Jupe, S  (2014-02-28)
Reviewed
Jassal, B  (2014-01-24)
Created
Jupe, S  (2014-02-28)
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