GPR37 binds prosaptide

Stable Identifier
R-HSA-5336182
Type
Reaction
Species
Homo sapiens
Compartment
extracellular region, plasma membrane
Locations in the PathwayBrowser
Expand all
Summation

GPR37 and GPR37L1 are almost exclusively expressed in the nervous system. They bind and are activated by the secreted neuroprotective and glioprotective factor prosaposin and a fragment of this named prosaptide. Signaling involves G-alpha-i/o.

Literature References
PubMed ID Title Journal Year
23690594 GPR37 and GPR37L1 are receptors for the neuroprotective and glioprotective factors prosaptide and prosaposin

Meyer, RC, Giddens, MM, Schaefer, SA, Hall, RA

Proc. Natl. Acad. Sci. U.S.A. 2013
Participants
Input
Output
Participant Of
hasEvent
Orthologous Events
GPR37 binds prosaptide (Bos taurus)
GPR37 binds prosaptide (Canis familiaris)
GPR37 binds prosaptide (Danio rerio)
GPR37 binds prosaptide (Drosophila melanogaster)
GPR37 binds prosaptide (Gallus gallus)
GPR37 binds prosaptide (Mus musculus)
GPR37 binds prosaptide (Rattus norvegicus)
GPR37 binds prosaptide (Sus scrofa)
GPR37 binds prosaptide (Taeniopygia guttata)
GPR37 binds prosaptide (Xenopus tropicalis)
Authored
Jupe, S  (2014-02-28)
Reviewed
Jassal, B  (2014-01-24)