DNMT3B:DNMT3L binds chromatin

Stable Identifier
R-HSA-5334164
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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The C-terminal region of DNMT3L associates with C-terminal regions of DNMT3B-isoform1 and DNMT3B-isoform2 (Chen et al. 2005, Van Emburgh and Robertson 2011, human DNMT3L with mouse Dnmt3b in Suetake et al. 2004). DNMT3L binds the unmethylated N-terminus of histone H3 (Ooi et al. 2007), leading DNMT3L to target DNMT3B to chromatin (Wienholz et al. 2010). As inferred from mouse homologs, DNMT3B also binds the unmodified N-terminus of histone H3.

Literature References
PubMed ID Title Journal Year
20838592 DNMT3L modulates significant and distinct flanking sequence preference for DNA methylation by DNMT3A and DNMT3B in vivo

Wienholz, BL, Kareta, MS, Moarefi, AH, Gordon, CA, Ginno, PA, Chédin, F

PLoS Genet. 2010
15861382 Physical and functional interactions between the human DNMT3L protein and members of the de novo methyltransferase family

Chen, ZX, Mann, JR, Hsieh, CL, Riggs, AD, Chédin, F

J. Cell. Biochem. 2005
15105426 DNMT3L stimulates the DNA methylation activity of Dnmt3a and Dnmt3b through a direct interaction

Suetake, I, Shinozaki, F, Miyagawa, J, Takeshima, H, Tajima, S

J. Biol. Chem. 2004
21378119 Modulation of Dnmt3b function in vitro by interactions with Dnmt3L, Dnmt3a and Dnmt3b splice variants

Van Emburgh, BO, Robertson, KD

Nucleic Acids Res. 2011
17687327 DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA

Ooi, SK, Qiu, C, Bernstein, E, Li, K, Jia, D, Yang, Z, Erdjument-Bromage, H, Tempst, P, Lin, SP, Allis, CD, Cheng, X, Bestor, TH

Nature 2007
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