CPNEs bind PL

Stable Identifier
R-HSA-5333678
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Copines bind phospholipid
ReviewStatus
5/5
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CPNEs bind PL
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Copine 1, 3, 6 and 7 (CPNE1,3,6,7) are a family of calcium-dependent phospholipid-binding proteins thought to be involved in membrane trafficking processes. They contain two C2 domains, one each for the Ca2+- and phospholipid-binding properties (Creutz et al. 1998, Tomsig & Creutz 2002).
Literature References
PubMed ID Title Journal Year
12440769 Copines: a ubiquitous family of Ca(2+)-dependent phospholipid-binding proteins

Tomsig, JL, Creutz, CE

Cell. Mol. Life Sci. 2002
9430674 The copines, a novel class of C2 domain-containing, calcium-dependent, phospholipid-binding proteins conserved from Paramecium to humans

Creutz, CE, Tomsig, JL, Snyder, SL, Gautier, MC, Skouri, F, Beisson, J, Cohen, J

J. Biol. Chem. 1998
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein-membrane adaptor activity of CPNEs [plasma membrane]

Physical Entity
CPNEs [plasma membrane] (Homo sapiens)
Activity
protein-membrane adaptor activity (GO:0043495)
This event is regulated
Positively by
Regulator
Ca2+ [cytosol]
Orthologous Events
CPNEs bind PL (Bos taurus)
CPNEs bind PL (Canis familiaris)
CPNEs bind PL (Danio rerio)
CPNEs bind PL (Dictyostelium discoideum)
CPNEs bind PL (Gallus gallus)
CPNEs bind PL (Mus musculus)
CPNEs bind PL (Rattus norvegicus)
CPNEs bind PL (Sus scrofa)
CPNEs bind PL (Xenopus tropicalis)
Authored
Jassal, B  (2014-02-20)
Reviewed
D'Eustachio, P  (2015-02-11)
Hill, DP  (2025-08-12)
Created
Jassal, B  (2014-02-20)
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