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CYP2A6 [endoplasmic reticulum membrane]
Stable Identifier
R-HSA-52659
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane
Synonyms
Cytochrome P450 2A6 , CYPIIA6, Coumarin 7-hydroxylase, IIA3, CYP2A3, P450(I)
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Biological oxidations (Homo sapiens)
Phase I - Functionalization of compounds (Homo sapiens)
Cytochrome P450 - arranged by substrate type (Homo sapiens)
Xenobiotics (Homo sapiens)
CYP2E1 reactions (Homo sapiens)
Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI) (Homo sapiens)
Cytochrome P450 (CYP2E1 based) [endoplasmic reticulum membrane] (Homo sapiens)
CYP2A6 [endoplasmic reticulum membrane] (Homo sapiens)
Benzene is hydroxylated to phenol (Homo sapiens)
Cytochrome P450 (CYP2E1 based) [endoplasmic reticulum membrane] (Homo sapiens)
CYP2A6 [endoplasmic reticulum membrane] (Homo sapiens)
Dehalogenation of carbon tetrachloride to form a free radical (Homo sapiens)
Cytochrome P450 (CYP2E1 based) [endoplasmic reticulum membrane] (Homo sapiens)
CYP2A6 [endoplasmic reticulum membrane] (Homo sapiens)
Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and hydrogen bromide (Homo sapiens)
Cytochrome P450 (CYP2E1 based) [endoplasmic reticulum membrane] (Homo sapiens)
CYP2A6 [endoplasmic reticulum membrane] (Homo sapiens)
MEOS oxidizes ethanol to acetaldehyde (Homo sapiens)
Cytochrome P450 (CYP2E1 based) [endoplasmic reticulum membrane] (Homo sapiens)
CYP2A6 [endoplasmic reticulum membrane] (Homo sapiens)
Vinyl chloride is oxidized to 2-Chloroethylene oxide (Homo sapiens)
Cytochrome P450 (CYP2E1 based) [endoplasmic reticulum membrane] (Homo sapiens)
CYP2A6 [endoplasmic reticulum membrane] (Homo sapiens)
CYP2F1 dehydrogenates 3-methylindole (Homo sapiens)
Cytochrome P450 (CYP2F1 based) [endoplasmic reticulum membrane] (Homo sapiens)
CYP2A6 [endoplasmic reticulum membrane] (Homo sapiens)
Coumarin is 7-hydroxylated by CYP2A13 (Homo sapiens)
Cytochrome P450 (CYP2A13 based) [endoplasmic reticulum membrane] (Homo sapiens)
CYP2A6 [endoplasmic reticulum membrane] (Homo sapiens)
Coumarin is 7-hydroxylated by CYP2A6 (Homo sapiens)
Cytochrome P450 (CYP2A3 based) [endoplasmic reticulum membrane] (Homo sapiens)
CYP2A6 [endoplasmic reticulum membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P11509 CYP2A6
Gene Names
CYP2A6, CYP2A3
Chain
chain:1-494
Reference Genes
BioGPS Gene:1548 CYP2A6
COSMIC (genes):CYP2A6 CYP2A6
CTD Gene:1548 CYP2A6
dbSNP Gene:1548 CYP2A6
ENSEMBL:ENSG00000255974 CYP2A6
ENSEMBL_homo_sapiens_GENE:ENSG00000255974.8 CYP2A6
HGNC:2610 CYP2A6
KEGG Gene (Homo sapiens):1548 CYP2A6
Monarch:1548 CYP2A6
NCBI Gene:1548 CYP2A6
UCSC:P11509 CYP2A6
Reference Transcript
RefSeq:NM_000762.5 CYP2A6
Other Identifiers
11726575_a_at
11726576_x_at
11742251_s_at
1338_s_at
1492_f_at
1493_r_at
1494_3p_f_at
1494_PM_f_at
1494_f_at
1548
1555_f_at
16872517
207244_3p_x_at
207244_PM_x_at
207244_x_at
211295_PM_x_at
211295_x_at
214320_PM_x_at
214320_x_at
3833949
3833952
3833953
3833955
3833956
3833960
3833963
3833964
3862888
3862889
3862890
3862893
3862894
3862896
3862897
3862898
3862899
3862900
3862901
3862945
3862946
3862955
3862956
3862957
3862958
3862959
3862969
3862975
8028973
8036969
A_23_P16122
GO:0003824
GO:0004497
GO:0005506
GO:0005737
GO:0005783
GO:0005789
GO:0005856
GO:0005881
GO:0006629
GO:0006805
GO:0008202
GO:0008389
GO:0008392
GO:0009804
GO:0016020
GO:0016491
GO:0016705
GO:0016712
GO:0019373
GO:0019899
GO:0020037
GO:0042178
GO:0043226
GO:0043231
GO:0046226
GO:0046872
HMNXSV003024973
ILMN_2091632
M33317_f_at
M33318_r_at
M33318mRNA_3p_s_at
PH_hs_0033441
TC19001549.hg
U22029_f_at
X13930_f_at
g13699805_3p_s_at
g13699808_3p_s_at
g4503216_3p_s_at
g6470138_3p_s_at
Participates
as a member of
Cytochrome P450 (CYP2A3 based) [endoplasmic reticulum membrane] (Homo sapiens)
as a candidate of
Cytochrome P450 (CYP2A13 based) [endoplasmic reticulum membrane] (Homo sapiens)
Cytochrome P450 (CYP2F1 based) [endoplasmic reticulum membrane] (Homo sapiens)
Cytochrome P450 (CYP2E1 based) [endoplasmic reticulum membrane] (Homo sapiens)
Inferred To
cyp-33e3 [endoplasmic reticulum membrane]
(Caenorhabditis elegans)
cyp-33c12 [endoplasmic reticulum membrane]
(Caenorhabditis elegans)
daf-9 [endoplasmic reticulum membrane]
(Caenorhabditis elegans)
CYP2A6 [endoplasmic reticulum membrane]
(Bos taurus)
CYP2A6 [endoplasmic reticulum membrane]
(Caenorhabditis elegans)
CYP2A6 [endoplasmic reticulum membrane]
(Canis familiaris)
CYP2A6 [endoplasmic reticulum membrane]
(Danio rerio)
CYP2A6 [endoplasmic reticulum membrane]
(Dictyostelium discoideum)
CYP2A6 [endoplasmic reticulum membrane]
(Drosophila melanogaster)
CYP2A6 [endoplasmic reticulum membrane]
(Mus musculus)
CYP2A6 [endoplasmic reticulum membrane]
(Rattus norvegicus)
CYP2A6 [endoplasmic reticulum membrane]
(Sus scrofa)
CYP2A6 [endoplasmic reticulum membrane]
(Xenopus tropicalis)
Homologues of CYP2A6 [endoplasmic reticulum membrane]
(Caenorhabditis elegans)
Homologues of CYP2A6 [endoplasmic reticulum membrane]
(Canis familiaris)
Homologues of CYP2A6 [endoplasmic reticulum membrane]
(Dictyostelium discoideum)
Homologues of CYP2A6 [endoplasmic reticulum membrane]
(Drosophila melanogaster)
Homologues of CYP2A6 [endoplasmic reticulum membrane]
(Mus musculus)
Homologues of CYP2A6 [endoplasmic reticulum membrane]
(Rattus norvegicus)
Homologues of CYP2A6 [endoplasmic reticulum membrane]
(Xenopus tropicalis)
Cross References
RefSeq
NP_000753.3
ZINC - World Drugs
CP2A6_HUMAN
Guide to Pharmacology - Targets
1321
OpenTargets
ENSG00000255974
ZINC - FDA approved
CP2A6_HUMAN
ZINC - Substances
CP2A6_HUMAN
ZINC target
P11509
ZINC - Biogenic
CP2A6_HUMAN
PRO
P11509
PDB
2FDY
,
3T3Q
,
2FDU
,
3EBS
,
2FDW
,
1Z11
,
1Z10
,
4RUI
,
3T3R
,
4EJJ
,
2FDV
ZINC - Investigational
CP2A6_HUMAN
ZINC - Metabolites
CP2A6_HUMAN
HPA
ENSG00000255974-CYP2A6
GeneCards
P11509
Ensembl
ENST00000301141
,
ENSG00000255974
,
ENSP00000301141
Pharos - Targets
P11509
ZINC - Predictions - Purchasable
CP2A6_HUMAN
Orphanet
27841
HMDB Protein
HMDBP01567
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
coumarin [ChEBI:28794]
2
COUM [endoplasmic reticulum lumen]
(R-ALL-76328)
coumarin [extracellular region]
(R-ALL-3296399)
0.558
2
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