ARL2:GTP:ARL2BP binds SLC25A4

Stable Identifier
R-HSA-5250209
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The complex between ADP-ribosylation factor-like protein 2-binding protein (ARL2BP aka BART) and GTP-bound ADP-ribosylation factor-like protein 2 (ARL2:GTP) is able to bind the ADP/ATP translocase 1 protein (SLC25A4 aka ANT1) at the mitochondrial inner membrane (Zhang et al. 2009, Bailey et al. 2009). ARL2 is essential for a number of mitochondrial functions, including mitochondrial morphology, motility and maintenance of ATP levels.

Literature References
PubMed ID Title Journal Year
18981177 The structure of binder of Arl2 (BART) reveals a novel G protein binding domain: implications for function

Bailey, LK, Campbell, LJ, Evetts, KA, Littlefield, K, Rajendra, E, Nietlispach, D, Owen, D, Mott, HR

J. Biol. Chem. 2009
19368893 Crystal structure of the ARL2-GTP-BART complex reveals a novel recognition and binding mode of small GTPase with effector

Zhang, T, Li, S, Zhang, Y, Zhong, C, Lai, Z, Ding, J

Structure 2009
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created
Cite Us!