The Botulinum toxin type B disulfide-bonded heavy chain - light chain dimer (botB HC:LC, encoded by the C. botulinum botB gene) (Swaminathan & Eswaramoorthy 2000) binds ganglioside GT1b and syntagmin 1 or 2 (SYT1 or 2) on the plasma membrane of a human target cell. In vivo, this process specifically targets synapses at neuromuscular junctions, where toxin association with ganglioside may position it to bind efficiently to SYT1 or 2 when those proteins are exposed at the cell surface by exocytosis (Dong et al. 2003). In vitro, botB HC:LC can bind gangliosides in addition to GT1b but with lower affinity (Kozaki et al. 1998). Only GT1b binding is annotated here.
Swaminathan, S, Eswaramoorthy, S
Tepp, WH, Chapman, ER, Dong, M, Goodnough, MC, Johnson, EA, Richards, DA
Mochida, S, Kamata, Y, Kozaki, S, Nishiki, T, Watarai, S
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