Reactome | PDE1C [cytosol]

PDE1C [cytosol]

Stable Identifier

R-HSA-52373

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C , Cam-PDE 1C, hCam-3

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Intracellular signaling by second messengers (Homo sapiens)
  - DAG and IP3 signaling (Homo sapiens)
    - CaM pathway (Homo sapiens)
      - Calmodulin induced events (Homo sapiens)
        
        Cam-PDE 1 activation (Homo sapiens)
        
        Calmodulin activates Cam-PDE 1 (Homo sapiens)
        
        PDE1 dimers [cytosol] (Homo sapiens)
        
        Cam-PDE 1C homodimer [cytosol] (Homo sapiens)
        
        PDE1C [cytosol] (Homo sapiens)
- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Opioid Signalling (Homo sapiens)
        
        G-protein mediated events (Homo sapiens)
        
        PLC beta mediated events (Homo sapiens)
        
        Ca-dependent events (Homo sapiens)
        
        CaM pathway (Homo sapiens)
        
        Calmodulin induced events (Homo sapiens)
        
        Cam-PDE 1 activation (Homo sapiens)
        
        Calmodulin activates Cam-PDE 1 (Homo sapiens)
        
        PDE1 dimers [cytosol] (Homo sapiens)
        
        Cam-PDE 1C homodimer [cytosol] (Homo sapiens)
        
        PDE1C [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q14123 PDE1C

Gene Names

PDE1C

Chain

chain:1-709

Reference Genes

BioGPS Gene:5137 PDE1C

COSMIC (genes):PDE1C PDE1C

CTD Gene:5137 PDE1C

dbSNP Gene:5137 PDE1C

ENSEMBL:ENSG00000154678.18 PDE1C

HGNC:8776 PDE1C

KEGG Gene (Homo sapiens):5137 PDE1C

Monarch:5137 PDE1C

NCBI Gene:5137 PDE1C

OMIM:602987 PDE1C

UCSC:Q14123 PDE1C

Reference Transcript

Other Identifiers

11737331_at

11744996_a_at

1554378_PM_a_at

1554378_a_at

17056426

207303_PM_at

207303_at

216869_PM_at

216869_at

236344_PM_at

236344_at

239218_PM_at

239218_at

3044612

3044613

3044614

3044623

3044624

3044625

3044626

3044627

3044628

3044629

3044630

3044631

3044634

3044641

3044643

3044644

3044645

3044646

3044650

3044652

3044654

3044655

3044659

3044660

3044661

3044676

3044677

3044678

3044679

3044680

32418_at

32419_at

5137

61879_at

79592_at

80397_at

8138888

A_23_P406508

A_24_P206328

A_33_P3331853

A_33_P3331856

GE59137

GE732091

GE809919

GE851074

GO:0003824

GO:0004114

GO:0004115

GO:0004117

GO:0005516

GO:0005764

GO:0005773

GO:0005829

GO:0007165

GO:0008081

GO:0016787

GO:0023052

GO:0043025

GO:0043226

GO:0046872

GO:0047555

GO:0048101

HMNXSV003015977

HMNXSV003017561

HMNXSV003019278

Hs.12024.0.A1_3p_at

Hs.143821.0.A1_3p_at

Hs.148334.0.A1_3p_at

Hs.41718.1.S1_3p_at

Hs2.41718.2.S1_3p_s_at

ILMN_1667225

ILMN_1830878

ILMN_1890773

PH_hs_0008481

PH_hs_0025161

PH_hs_0033275

TC07001256.hg

TC07002874.hg

U40371_at

U40372_at

g4826893_3p_at

p26384

p26385

Participates

as a component of

Cam-PDE 1C homodimer [cytosol] (Homo sapiens)

Other forms of this molecule

activated PDE1C [cytosol]

Inferred To

Homologues of activated PDE1C [cytosol] (Plasmodium falciparum)

activated PDE1C [cytosol] (Bos taurus)

activated PDE1C [cytosol] (Caenorhabditis elegans)

activated PDE1C [cytosol] (Canis familiaris)

activated PDE1C [cytosol] (Danio rerio)

activated PDE1C [cytosol] (Dictyostelium discoideum)

activated PDE1C [cytosol] (Drosophila melanogaster)

activated PDE1C [cytosol] (Gallus gallus)

activated PDE1C [cytosol] (Mus musculus)

activated PDE1C [cytosol] (Plasmodium falciparum)

activated PDE1C [cytosol] (Rattus norvegicus)

activated PDE1C [cytosol] (Sus scrofa)

activated PDE1C [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_001177987.2, XP_016867756.1, NP_001177986.1, NP_001177988.1, NP_001308986.1, NP_001308984.1, NP_001308987.1, NP_005011.1, NP_001177985.1, NP_001308988.1, NP_001308985.1

Guide to Pharmacology - Targets

1296

OpenTargets

ENSG00000154678

ZINC - Substances

PDE1C_HUMAN

ZINC target

Q14123

PRO

Q14123

ZINC - Investigational

PDE1C_HUMAN

HPA

ENSG00000154678-PDE1C

GeneCards

Q14123

Ensembl

ENST00000396191, ENST00000321453, ENSP00000318105, ENSG00000154678, ENST00000396184, ENSP00000379494, ENST00000396182, ENSP00000379485, ENSP00000379487

Pharos - Targets

Q14123

ZINC - Predictions - Purchasable

PDE1C_HUMAN

Orphanet

27306

HMDB Protein

HMDBP00605