AP4 transports APP from trans-Golgi network to endosome lumen

Stable Identifier
R-HSA-5229111
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
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AP-4 complex subunit mu-1 (AP4M1) can recognise and interact with tyrosine-based (YXXphi) sorting signals found within the cytoplasmic tails of integral membrane proteins such as the amyloid precursor protein (APP), implicated in Alzheimer's disease. Once bound to AP4M1, APP is transported from the trans-Golgi network (TGN) to endosomes, thereby reducing amyloidogenic processing of the protein. Disruption of this interaction decreases localisation of APP to endosomes and enhances gamma-secretase-catalysed cleavage of APP to the pathogenic amyloid-beta peptide (Burgos et al. 2010).

Literature References
PubMed ID Title Journal Year
20230749 Sorting of the Alzheimer's disease amyloid precursor protein mediated by the AP-4 complex

Burgos, PV, Mardones, GA, Rojas, AL, daSilva, LL, Prabhu, Y, Hurley, JH, Bonifacino, JS

Dev. Cell 2010
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein transmembrane transporter activity of AP4:APP [trans-Golgi network membrane]
Physical Entity
Activity
Orthologous Events
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