Transcytosis and dissociation of BoNT/E:NTNHA

Stable Identifier
R-HSA-5228941
Type
Reaction [omitted]
Species
Homo sapiens
Related Species
Clostridium botulinum
Compartment
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The bacterial BoNT/E:NTNHA complex, consisting of a Botulinum toxin type E (BoNT/E) disulfide bonded heavy chain (HC) - light chain (LC) heterodimer (“dichain”) associated with nontoxic nonhemagglutinin protein (NTNHA) (Benefield et al. 2013), associates with the plasma membrane of a human cell (in vivo, the apical surface of a gut epithelial cell) and undergoes transcytosis. While the molecular details of transcytosis remain to be established definitively, the process enables the toxin heterodimer to cross the epithelial cell layer and enter the circulation (Fujinaga et al. 2013; Simpson 2004).

Literature References
PubMed ID Title Journal Year
23509303 Molecular assembly of botulinum neurotoxin progenitor complexes

Benefield, DA, Dessain, SK, Shine, N, Ohi, MD, Lacy, DB

Proc. Natl. Acad. Sci. U.S.A. 2013
23239348 Uptake of botulinum neurotoxin in the intestine

Fujinaga, Y, Sugawara, Y, Matsumura, T

Curr. Top. Microbiol. Immunol. 2013
14744243 Identification of the major steps in botulinum toxin action

Simpson, LL

Annu. Rev. Pharmacol. Toxicol. 2004
Participants
Participant Of
Disease
Name Identifier Synonyms
botulism 11976 Botulism (disorder), Intoxication with Clostridium botulinum toxin, Botulism, Infection due to clostridium botulinum, Botulism, Foodborne botulism, botulism, Botulism, Botulism, Botulism, Food poisoning due to Clostridium botulinum, Botulism poisoning
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