Transcytosis and dissociation of botE:NTNHA

Stable Identifier
R-HSA-5228941
Type
Reaction [omitted]
Species
Homo sapiens
Related Species
Clostridium botulinum
Compartment
extracellular region
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Transcytosis and dissociation of botE:NTNHA
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The bacterial botE:NTNHA complex, consisting of a Botulinum toxin type E (botE, also known as BoNT/E) disulfide bonded heavy chain (HC) - light chain (LC) heterodimer (“dichain”) associated with nontoxic nonhemagglutinin protein (NTNHA) (Benefield et al. 2013), associates with the plasma membrane of a human cell (in vivo, the apical surface of a gut epithelial cell) and undergoes transcytosis. While the molecular details of transcytosis remain to be established definitively, the process enables the toxin heterodimer to cross the epithelial cell layer and enter the circulation (Fujinaga et al. 2013; Simpson 2004).
Literature References
PubMed ID Title Journal Year
23239348 Uptake of botulinum neurotoxin in the intestine

Matsumura, T, Fujinaga, Y, Sugawara, Y

Curr. Top. Microbiol. Immunol. 2013
23509303 Molecular assembly of botulinum neurotoxin progenitor complexes

Ohi, MD, Lacy, DB, Dessain, SK, Benefield, DA, Shine, N

Proc. Natl. Acad. Sci. U.S.A. 2013
14744243 Identification of the major steps in botulinum toxin action

Simpson, LL

Annu. Rev. Pharmacol. Toxicol. 2004
Participants
Input
Output
Participates
as an event of
Disease
Name Identifier Synonyms
botulism DOID:11976 Botulism (disorder), Intoxication with Clostridium botulinum toxin, Botulism, Infection due to clostridium botulinum, Botulism, Foodborne botulism, botulism, Botulism, Botulism, Botulism, Food poisoning due to Clostridium botulinum, Botulism poisoning
Authored
Gopinathrao, G  (2006-06-15)
Krupa, S  (2006-06-15)
Reviewed
Ichtchenko, K  (2007-08-03)
Thirunavukkarasu, N  (2014-11-18)
Sharma, S  (2014-11-18)
Created
D'Eustachio, P  (2014-01-15)
Cite Us!