The bacterial botB:NTNHA:HA (BoNT/B:NTNHA:HA) complex,, consisting of a Botulinum toxin type B (botB) disulfide bonded heavy chain (HC) - light chain (LC) dimer associated with nontoxic nonhemagglutinin protein (NTNHA), three molecules of hemagglutinin (ha) 17, six of ha33, and three of ha70 (Amatsu et al. 2013), associates with the plasma membrane of a human cell (in vivo, the apical surface of a gut epithelial cell) and undergoes transcytosis. While the molecular details of transcytosis remain to be established definitively, the process enables the toxin heterodimer to cross the epithelial cell layer and enter the circulation (Fujinaga et al. 2013; Simpson 2004).
Matsumura, T, Fujinaga, Y, Sugawara, Y
Matsumura, T, Kitadokoro, K, Fujinaga, Y, Amatsu, S, Sugawara, Y
Simpson, LL
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