RBBP7 binds histone H3

Stable Identifier
R-HSA-5225649
Type
Reaction [binding]
Species
Homo sapiens
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RBBP7, a central component of the co-repressor complexes Sin3a, NURD and PRC2, can bind histone H3 arginine-3 (H3R2). Symmetrical dimethylation of this residue excludes RBBP7 binding but enhances binding of WDR5, a common component of the coactivator complexes MLL, SET1A, SET1B, NLS1 and ATAC (Migliori et al. 2012).

Literature References
PubMed ID Title Journal Year
22231400 Symmetric dimethylation of H3R2 is a newly identified histone mark that supports euchromatin maintenance

Migliori, V, Müller, J, Phalke, S, Low, D, Bezzi, M, Mok, WC, Sahu, SK, Gunaratne, J, Capasso, P, Bassi, C, Cecatiello, V, De Marco, A, Blackstock, W, Kuznetsov, V, Amati, B, Mapelli, M, Guccione, E

Nat. Struct. Mol. Biol. 2012
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