Reactome | WDR5 binds Me2sR3-replicative histone H3

WDR5 binds Me2sR3-replicative histone H3

Stable Identifier

R-HSA-5225602

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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WDR5 binds Me2sR3-replicative histone H3

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Symmetric dimethylation of histone H3 arginine-3 (H3R2) enhances binding of WDR5, a component of the coactivator complexes MLL, SET1A, SET1B, NLS1 and ATAC (Migliori et al. 2012).

Literature References

PubMed ID	Title	Journal	Year
22231400	Symmetric dimethylation of H3R2 is a newly identified histone mark that supports euchromatin maintenance Guccione, E, Cecatiello, V, Sahu, SK, Mapelli, M, Bezzi, M, Bassi, C, Migliori, V, Capasso, P, Low, D, Müller, J, Kuznetsov, V, De Marco, A, Blackstock, W, Gunaratne, J, Mok, WC, Phalke, S, Amati, B	Nat. Struct. Mol. Biol.	2012