PKC autophosphorylates

Stable Identifier
R-HSA-5218805
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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After phosphorylation by PDK1, PKC undergoes autophosphorylation at two sites important for PKC activity, one in the turn motif (Thr-642 in PKCB) and the second in the hydrophobic phosphorylation motif (Ser-661 in PKCB). These phosphorylations render the enzyme catalytically competent but still inactive; diacylglycerol (DAG) and calcium are required for full activation.

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein kinase C activity of p-PKCA,p-PKCB,p-PKCZ,p-PKCD [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created