Reactome | PKC autophosphorylates

PKC autophosphorylates

Stable Identifier

R-HSA-5218805

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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After phosphorylation by PDK1, PKC undergoes autophosphorylation at two sites important for PKC activity, one in the turn motif (Thr-642 in PKCB) and the second in the hydrophobic phosphorylation motif (Ser-661 in PKCB). These phosphorylations render the enzyme catalytically competent but still inactive; diacylglycerol (DAG) and calcium are required for full activation.

Literature References

PubMed ID	Title	Journal	Year
9218480	Phosphorylation at conserved carboxyl-terminal hydrophobic motif regulates the catalytic and regulatory domains of protein kinase C Newton, AC, Edwards, AS	J. Biol. Chem.	1997
10421574	The hydrophobic phosphorylation motif of conventional protein kinase C is regulated by autophosphorylation Newton, AC, Behn-Krappa, A	Curr. Biol.	1999