After phosphorylation by PDK1, PKC undergoes autophosphorylation at two sites important for PKC activity, one in the turn motif (Thr-642 in PKCB) and the second in the hydrophobic phosphorylation motif (Ser-661 in PKCB). These phosphorylations render the enzyme catalytically competent but still inactive; diacylglycerol (DAG) and calcium are required for full activation.
Newton, AC, Edwards, AS
Newton, AC, Behn-Krappa, A
protein kinase C activity of p-PKCA,p-PKCB,p-PKCZ,p-PKCD [cytosol]
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