Endocytosis of cya:lef:(pagA(197-794):ANTXR1 oligomer) (plasma membrane to endosome membrane)

Stable Identifier
Reaction [omitted]
Homo sapiens
Related Species
Bacillus anthracis
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cya (Anthrax EF, edema factor) and lef (LF, lethal factor) toxins bound to pagA(197-794):ANTXR1 (protective antigen, large fragment:Anthrax receptor 1) oligomer on the plasma membrane of the target cell, are localized into clathrin coated vesicles and transported to endosomes. Depletion of target cell ARAP3 (ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3) partly blocks endocytosis (Lu et al. 2004), but this effect may be indirect and has not been characterized at a molecular level (van der Goot & Young 2009).

Literature References
PubMed ID Title Journal Year
12551953 Anthrax toxin triggers endocytosis of its receptor via a lipid raft-mediated clathrin-dependent process

Leppla, SH, Liu, S, van der Goot, FG, Abrami, L, Cosson, P

J. Cell Biol. 2003
15569923 EST-based genome-wide gene inactivation identifies ARAP3 as a host protein affecting cellular susceptibility to anthrax toxin

Lu, Q, Cohen, SN, Kowalski, PE, Chang, AC, Wei, W

Proc. Natl. Acad. Sci. U.S.A. 2004
19732789 Receptors of anthrax toxin and cell entry

Young, JA, van der Goot, FG

Mol. Aspects Med. 2009
Name Identifier Synonyms
anthrax disease DOID:7427
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