Endocytosis of cya:lef:(pagA(197-794):ANTXR1 oligomer) (plasma membrane to endosome membrane)

Stable Identifier
R-HSA-5210944
Type
Reaction [omitted]
Species
Homo sapiens
Related Species
Bacillus anthracis
Compartment
plasma membrane, endosome membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Endocytosis of cya:lef:(pagA(197-794):ANTXR1 oligomer) (plasma membrane to endosome membrane)
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
cya (Anthrax EF, edema factor) and lef (LF, lethal factor) toxins bound to pagA(197-794):ANTXR1 (protective antigen, large fragment:Anthrax receptor 1) oligomer on the plasma membrane of the target cell, are localized into clathrin coated vesicles and transported to endosomes. Depletion of target cell ARAP3 (ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3) partly blocks endocytosis (Lu et al. 2004), but this effect may be indirect and has not been characterized at a molecular level (van der Goot & Young 2009).
Literature References
PubMed ID Title Journal Year
12551953 Anthrax toxin triggers endocytosis of its receptor via a lipid raft-mediated clathrin-dependent process

Abrami, L, Liu, S, Cosson, P, Leppla, SH, van der Goot, FG

J. Cell Biol. 2003
15569923 EST-based genome-wide gene inactivation identifies ARAP3 as a host protein affecting cellular susceptibility to anthrax toxin

Lu, Q, Wei, W, Kowalski, PE, Chang, AC, Cohen, SN

Proc. Natl. Acad. Sci. U.S.A. 2004
19732789 Receptors of anthrax toxin and cell entry

van der Goot, FG, Young, JA

Mol. Aspects Med. 2009
Participants
Input
Output
Participates
as an event of
Disease
Name Identifier Synonyms
anthrax disease DOID:7427
Cross References
Mondo
Authored
D'Eustachio, P  (2013-12-13)
Reviewed
Leppla, SH  (2014-05-19)
Liu, S  (2014-05-28)
Moayeri, M  (2014-05-28)
Turk, BE  (2014-05-23)
Created
D'Eustachio, P  (2013-12-08)
Cite Us!