pagA binds ANTXR1

Stable Identifier
R-HSA-5210921
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Bacillus anthracis
Compartment
extracellular region, plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
pagA binds ANTXR1
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Extracellular pagA (also known as PA83 - full length Protective Antigen - Petosa et al. 1997) produced by Bacillus anthracis binds to either of two isoforms of ANTXR1 (Anthrax Toxin Receptor 1, also known as TEM8 - Bradley et al. 2001; Liu and Leppla 2003) in the plasma membrane of a target human cell. The physiological ligand for ANTXR1 is not known nor are the physiological roles of the two ANTRX1 isoforms. Although ANTXR1 can act as a relatively low affinity pagA receptor in tissue culture model systems, it does not play a primary role in anthrax toxin induced effects in mouse models (Liu et al. 2009). While some studies suggest that ANTXR1 is associated with palmitoylated LRP6 (low density lipoprotein receptor related protein 6 - Abrami et al. 2008) in the plasma membrane and that the latter molecule can function as a co-receptor (Wei et al. 2006), the role of LRP6 in PA83 uptake remains uncertain (reviewed by van der Goot & Young 2009) and no function for LRP6 is annotated here.
Literature References
PubMed ID Title Journal Year
9039918 Crystal structure of the anthrax toxin protective antigen

Klimpel, KR, Leppla, SH, Petosa, C, Collier, RJ, Liddington, RC

Nature 1997
18717822 Functional interactions between anthrax toxin receptors and the WNT signalling protein LRP6

van der Goot, FG, Abrami, L, Kunz, B, Davidson, G, Bafico, A, Deuquet, J

Cell. Microbiol. 2008
12468536 Cell surface tumor endothelium marker 8 cytoplasmic tail-independent anthrax toxin binding, proteolytic processing, oligomer formation, and internalization

Leppla, SH, Liu, S

J. Biol. Chem. 2003
19732789 Receptors of anthrax toxin and cell entry

Young, JA, van der Goot, FG

Mol. Aspects Med. 2009
11700562 Identification of the cellular receptor for anthrax toxin

Young, JA, Mogridge, J, Mourez, M, Bradley, KA, Collier, RJ

Nature 2001
16564009 The LDL receptor-related protein LRP6 mediates internalization and lethality of anthrax toxin

Lu, Q, Leppla, SH, Cohen, SN, Wei, W, Chaudry, GJ

Cell 2006
19617532 Capillary morphogenesis protein-2 is the major receptor mediating lethality of anthrax toxin in vivo

Leppla, SH, Liu, S, Hu, H, Crown, D, Wang, H, Miller-Randolph, S, Morley, T, Moayeri, M

Proc. Natl. Acad. Sci. U.S.A. 2009
Participants
Input
Output
Participates
as an event of
Disease
Name Identifier Synonyms
anthrax disease DOID:7427
Authored
D'Eustachio, P  (2013-12-13)
Reviewed
Leppla, SH  (2014-05-19)
Moayeri, M  (2014-05-28)
Turk, BE  (2014-05-23)
Liu, S  (2014-05-28)
Created
D'Eustachio, P  (2013-12-07)
Cite Us!