ANTXR1-bound pagA(197-794) forms oligomers

Stable Identifier
R-HSA-5210909
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Bacillus anthracis
Compartment
plasma membrane
ReviewStatus
5/5
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ANTXR1-bound pagA(197-794) forms oligomers
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ANTXR1 (Anthrax Receptor 1)-bound pagA(197-794) (protective antigen, large fragment) forms oligomers in the target cell plasma membrane. Initial studies indicated that these were heptamers (Lacy et al. 2004; Santelli et al. 2004; Wigelsworth et al. 2004; Young and Collier 2007). More recent work has established that octamers also form and suggests that the octaneric structure is more stable under physiological conditions (Kintzer et al. 2009, 2010). Formation of the latter structure is thus annotated here.
Literature References
PubMed ID Title Journal Year
17335404 Anthrax toxin: receptor binding, internalization, pore formation, and translocation

Young, JA, Collier, RJ

Annu. Rev. Biochem. 2007
15326297 Structure of heptameric protective antigen bound to an anthrax toxin receptor: a role for receptor in pH-dependent pore formation

Lacy, DB, Wigelsworth, DJ, Melnyk, RA, Harrison, SC, Collier, RJ

Proc. Natl. Acad. Sci. U.S.A. 2004
20433851 Role of the protective antigen octamer in the molecular mechanism of anthrax lethal toxin stabilization in plasma

Kintzer, AF, Sterling, HJ, Tang, II, Abdul-Gader, A, Miles, AJ, Wallace, BA, Williams, ER, Krantz, BA

J. Mol. Biol. 2010
15044490 Binding stoichiometry and kinetics of the interaction of a human anthrax toxin receptor, CMG2, with protective antigen

Wigelsworth, DJ, Krantz, BA, Christensen, KA, Lacy, DB, Juris, SJ, Collier, RJ

J. Biol. Chem. 2004
15243628 Crystal structure of a complex between anthrax toxin and its host cell receptor

Santelli, E, Bankston, LA, Leppla, SH, Liddington, RC

Nature 2004
19627991 The protective antigen component of anthrax toxin forms functional octameric complexes

Kintzer, AF, Thoren, KL, Sterling, HJ, Dong, KC, Feld, GK, Tang, II, Zhang, TT, Williams, ER, Berger, JM, Krantz, BA

J. Mol. Biol. 2009
Participants
Input
Output
Participates
as an event of
Disease
Name Identifier Synonyms
anthrax disease DOID:7427
Cross References
Mondo
Authored
D'Eustachio, P  (2013-12-13)
Reviewed
Leppla, SH  (2014-05-19)
Liu, S  (2014-05-28)
Moayeri, M  (2014-05-28)
Turk, BE  (2014-05-23)
Created
D'Eustachio, P  (2013-12-07)
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