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RRP8 binds RNA
Stable Identifier
R-HSA-5096488
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Gene expression (Transcription) (Homo sapiens)
Epigenetic regulation of gene expression (Homo sapiens)
Negative epigenetic regulation of rRNA expression (Homo sapiens)
SIRT1 negatively regulates rRNA expression (Homo sapiens)
RRP8 binds RNA (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
RRP8 (Nucleomethylin, NML) recruits SIRT1 to the nucleolus to form the energy-dependent Nucleolar Silencing Complex (eNoSC), which induces chromatin changes that inhibit rRNA transcription. RRP8 can bind 5S RNA (transcribed by RNA ploymerase III), 5.8S rRNA, and 28S rRNA and the bound RNA prevents RRP8 from binding SIRT1 (Yang et al. 2013). Thus the level of 5S RNA, 5.8S rRNA, and 28S rRNA in the nucleus negatively regulates the assembly of eNoSC, coupling transcriptional regulation of rRNA to epigenetic silencing of rRNA genes.
Literature References
PubMed ID
Title
Journal
Year
23897426
Regulation of SirT1-nucleomethylin binding by rRNA coordinates ribosome biogenesis with nutrient availability
Zheng, H
,
Chen, L
,
Chen, J
,
Seto, E
,
Song, T
,
Yang, L
,
Kabra, N
,
Koomen, J
Mol. Cell. Biol.
2013
Participants
Input
5S RNA, 5.8S rRNA, 28S rRNA [nucleoplasm]
(Homo sapiens)
RRP8 [nucleoplasm]
(Homo sapiens)
Output
RRP8:5S RNA, rRNA [nucleoplasm]
(Homo sapiens)
Participates
as an event of
SIRT1 negatively regulates rRNA expression (Homo sapiens)
Authored
May, B (2013-11-10)
Reviewed
Voit, R (2014-01-21)
Grummt, I (2014-01-21)
Created
May, B (2013-11-10)
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