Reactome | PTK2B is phosphorylated

PTK2B is phosphorylated

Stable Identifier

R-HSA-508451

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Pyk2 is activated following IL2 stimulation

ReviewStatus

5/5

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The proline rich tyrosine kinase 2 (PYK2) is a nonreceptor protein tyrosine kinase that is structurally related to FAK and thought to be important for leukocyte activation (Ostergaard & Lysechko, 2005). PYK2 tyrosine phosphorlation is known to occur downstream of IL-2 stimulation in human peripheral T lymphocytes. This phosphorylation can be prevented by blocking IL-2 mediated JAK activity. Although the function of Pyk2 within the IL-2 signaling pathways remains uncertain, a dominant negative mutant of Pyk2 inhibited IL-2-induced cell proliferation without affecting Stat5 activation which suggests that Pyk2 does indeed influence IL-2 driven immune cell responses.

Literature References

PubMed ID	Title	Journal	Year
9512511	Pyk2 is a downstream mediator of the IL-2 receptor-coupled Jak signaling pathway Taniguchi, T, Schlessinger, J, Mitani, Y, Miyazaki, T, Takaoka, A, Tsujino, S, Fujii, H, Dikic, I, Maeda, M, Nogueira, L	Genes Dev	1998