Secretion of SOD3

Stable Identifier
R-HSA-4837364
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
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SOD3 is secreted from cells into the extracellular region. Before secretion a portion of SOD3 molecules are cleaved near the C-terminus at glutamate-227 (glutamate-209 in the mature protein) (Olsen et al. 2004, Karlsson et al. 1993). Removal of the C-terminus prevents interaction with the extracellular matrix so cleaved molecules are soluble. Cleaved and uncleaved molecules are believed to be capable of forming mixed tetramers (Sandstrom et al. 1993).

Literature References
PubMed ID Title Journal Year
15044467 The intracellular proteolytic processing of extracellular superoxide dismutase (EC-SOD) is a two-step event

Olsen, DA, Petersen, SV, Oury, TD, Valnickova, Z, Thøgersen, IB, Kristensen, T, Bowler, RP, Crapo, JD, Enghild, JJ

J. Biol. Chem. 2004
8452552 Proteolytic modification of the heparin-binding affinity of extracellular superoxide dismutase

Karlsson, K, Edlund, A, Sandström, J, Marklund, SL

Biochem. J. 1993
8379940 Heparin-affinity patterns and composition of extracellular superoxide dismutase in human plasma and tissues

Sandström, J, Karlsson, K, Edlund, T, Marklund, SL

Biochem. J. 1993
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