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polySUMO3-NR1I2 [nucleoplasm]
Stable Identifier
R-HSA-4755523
Type
Genes and Transcripts [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Nuclear receptor subfamily 1 group I member 2, NR1I2_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
SUMOylation (Homo sapiens)
SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
SUMOylation of intracellular receptors (Homo sapiens)
SUMOylation of NR1I2 with SUMO3 (Homo sapiens)
SUMO3-NR1I2:rifampicin [nucleoplasm] (Homo sapiens)
polySUMO3-NR1I2 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:O75469-1 NR1I2
Gene Names
NR1I2, PXR
Other Identifiers
11738805_a_at
11740333_a_at
16944464
207202_PM_s_at
207202_s_at
207203_PM_s_at
207203_s_at
2638176
2638178
2638179
2638180
2638181
2638182
2638183
2638184
2638185
2638186
2638190
2638191
2638192
2638198
2638199
2638200
2638201
2638202
2638203
2638206
2638208
2638209
2638212
2638213
2638214
2638215
35114_at
8081925
8856
A_14_P132184
A_23_P109785
GE55185
GO:0000122
GO:0000785
GO:0000977
GO:0000978
GO:0000981
GO:0001228
GO:0003677
GO:0003700
GO:0004879
GO:0005515
GO:0005634
GO:0005654
GO:0005667
GO:0005856
GO:0006355
GO:0006629
GO:0006805
GO:0007165
GO:0008202
GO:0008270
GO:0010628
GO:0016604
GO:0016922
GO:0030154
GO:0030522
GO:0042178
GO:0042908
GO:0043226
GO:0043565
GO:0045111
GO:0045892
GO:0045893
GO:0045944
GO:0046872
GO:0060089
GO:0140110
GO:1990837
HMNXSV003033700
ILMN_1806561
ILMN_2240109
ILMN_2323338
PH_hs_0006489
TC03000613.hg
g11863133_3p_a_at
g3511137_3p_a_at
Participates
as a component of
SUMO3-NR1I2:rifampicin [nucleoplasm] (Homo sapiens)
Other forms of this molecule
NR1I2-1 [nucleoplasm]
Inferred To
polySUMO3-NR1I2 [nucleoplasm]
(Mus musculus)
polySUMO3-NR1I2 [nucleoplasm]
(Rattus norvegicus)
NR1I2 [nucleoplasm]
(Bos taurus)
NR1I2 [nucleoplasm]
(Sus scrofa)
nr1i2 [nucleoplasm]
(Danio rerio)
Hr96 [nucleoplasm]
(Drosophila melanogaster)
Modified Residues
Name
sumoylated lysine (polySUMO3 [nucleoplasm]) at unknown position
Modification
polySUMO3 [nucleoplasm]
PsiMod Name
sumoylated lysine
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.
Cross References
ZINC - World Drugs
NR1I2_HUMAN
Guide to Pharmacology - Targets
606
OpenTargets
ENSG00000144852
ENSEMBL
ENSP00000420297
,
ENST00000337940
,
ENST00000466380
,
ENST00000393716
,
ENSP00000336528
,
ENSP00000377319
ZINC - FDA approved
NR1I2_HUMAN
ZINC - Substances
NR1I2_HUMAN
ZINC - Biogenic
NR1I2_HUMAN
ZINC target
O75469
PRO
O75469
PDB
8CCT
,
4S0S
,
1M13
,
1NRL
,
1SKX
,
1ILH
,
7AXL
,
7AXE
,
2QNV
,
7RIO
,
8SVP
,
8SZV
,
8SVQ
,
8SVT
,
8SVU
,
8SVS
,
6BNS
,
7N2A
,
6HJ2
,
8EQZ
,
3HVL
,
7RIU
,
6DUP
,
7AXB
,
7AXJ
,
7AX8
,
7AXH
,
7YFK
,
7AXA
,
5A86
,
8E3N
,
6XP9
,
6TFI
,
4X1G
,
7AXG
,
4X1F
,
4S0T
,
8FPE
,
8CH8
,
1ILG
,
6NX1
,
6HTY
,
7AXD
,
8SVX
,
8SVR
,
8SVO
,
4NY9
,
8SVN
,
6S41
,
4J5W
,
7RIV
,
6P2B
,
2O9I
,
7AXC
,
7AXK
,
3CTB
,
7AX9
,
3R8D
,
7AXI
,
5X0R
,
4XHD
,
4XAO
,
8F5Y
,
8CF9
,
7AXF
,
4J5X
ZINC - Investigational
NR1I2_HUMAN
ZINC - Metabolites
NR1I2_HUMAN
HPA
ENSG00000144852-NR1I2
Pharos - Targets
O75469
ZINC - Predictions - Purchasable
NR1I2_HUMAN
HMDB Protein
HMDBP02048
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q15788 NCOA1
3
NCOA1 [nucleoplasm]
(R-HSA-442496)
NCOA1 (868-1441) [nucleoplasm]
(R-HSA-5603230)
monoSUMO1-K732,K774-NCOA1 [nucleoplasm]
(R-HSA-4085291)
0.602
5
UniProt:P08238 HSP90AB1
6
HSP90AB1 [lysosomal lumen]
(R-HSA-9622846)
HSP90AB1 [nucleoplasm]
(R-HSA-5082399)
HSP90AB1 [cytosol]
(R-HSA-419617)
HSP90AB1 [secretory granule lumen]
(R-HSA-6801477)
HSP90AB1 [extracellular region]
(R-HSA-6806463)
HSP90AB1 [ficolin-1-rich granule lumen]
(R-HSA-6801491)
0.524
2
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