PIAS1,2-1 SUMOylate NR5A2 with SUMO1

Stable Identifier
Reaction [transition]
Homo sapiens
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PIAS1,2-1 SUMOylate NR5A2 (LRH-1) with SUMO1 at lysine-270 (lysine-224 in the shorter isoform) (Chalkiadaki and Talianidis 2005, Ogawa et al. 2009, Venteclef et al. 2010). SUMOylation is enhanced when NR5A2 is bound to ligand. SUMOylated NR5A2 acts as a transrepressor of genes involved in inflammation such as haptoglobin, SAA, and CRP.

Literature References
PubMed ID Title Journal Year
19692572 Transcriptional Suppression by Transient Recruitment of ARIP4 to Sumoylated nuclear receptor Ad4BP/SF-1

Hiraoka, Y, Komatsu, T, Ogawa, H, Morohashi, K

Mol. Biol. Cell 2009
20159957 GPS2-dependent corepressor/SUMO pathways govern anti-inflammatory actions of LRH-1 and LXRbeta in the hepatic acute phase response

Jakobsson, T, Parini, P, Damdimopoulos, A, Jänne, OA, Gustafsson, JA, Nilsson, LM, Steffensen, KR, Ehrlund, A, Venteclef, N, Treuter, E, Ellis, E, Mikkonen, L

Genes Dev. 2010
15923626 SUMO-dependent compartmentalization in promyelocytic leukemia protein nuclear bodies prevents the access of LRH-1 to chromatin

Talianidis, I, Chalkiadaki, A

Mol. Cell. Biol. 2005
Catalyst Activity

SUMO transferase activity of PIAS1,2-1 [nucleoplasm]

Orthologous Events
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