Reactome | PIAS1,2-1 SUMOylate NR5A2 with SUMO1

PIAS1,2-1 SUMOylate NR5A2 with SUMO1

Stable Identifier

R-HSA-4755494

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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PIAS1,2-1 SUMOylate NR5A2 (LRH-1) with SUMO1 at lysine-270 (lysine-224 in the shorter isoform) (Chalkiadaki and Talianidis 2005, Ogawa et al. 2009, Venteclef et al. 2010). SUMOylation is enhanced when NR5A2 is bound to ligand. SUMOylated NR5A2 acts as a transrepressor of genes involved in inflammation such as haptoglobin, SAA, and CRP.

Literature References

PubMed ID	Title	Journal	Year
19692572	Transcriptional Suppression by Transient Recruitment of ARIP4 to Sumoylated nuclear receptor Ad4BP/SF-1 Ogawa, H, Komatsu, T, Hiraoka, Y, Morohashi, K	Mol. Biol. Cell	2009
20159957	GPS2-dependent corepressor/SUMO pathways govern anti-inflammatory actions of LRH-1 and LXRbeta in the hepatic acute phase response Venteclef, N, Jakobsson, T, Ehrlund, A, Damdimopoulos, A, Mikkonen, L, Ellis, E, Nilsson, LM, Parini, P, Jänne, OA, Gustafsson, JA, Steffensen, KR, Treuter, E	Genes Dev.	2010
15923626	SUMO-dependent compartmentalization in promyelocytic leukemia protein nuclear bodies prevents the access of LRH-1 to chromatin Chalkiadaki, A, Talianidis, I	Mol. Cell. Biol.	2005