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EP400 binds CDKN1A promoter
Stable Identifier
R-HSA-4647593
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular Senescence (Homo sapiens)
DNA Damage/Telomere Stress Induced Senescence (Homo sapiens)
EP400 binds CDKN1A promoter (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
EP400 (p400) binds to a CDKN1A promoter region that overlaps with the distal TP53-binding site and can co-localize with TP53 on CDKN1A promoter (Chan et al. 2005).
Literature References
PubMed ID
Title
Journal
Year
15655109
The p400 E1A-associated protein is a novel component of the p53 --> p21 senescence pathway
Livingston, DM
,
Lowe, SW
,
Narita, M
,
Chan, HM
Genes Dev.
2005
Participants
Input
EP400 [nucleoplasm]
(Homo sapiens)
p-S15-TP53 Tetramer:CDKN1A Gene [nucleoplasm]
(Homo sapiens)
Output
EP400:p-S15-TP53 Tetramer:CDKN1A Gene [nucleoplasm]
(Homo sapiens)
Participates
as an event of
DNA Damage/Telomere Stress Induced Senescence (Homo sapiens)
Orthologous Events
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EP400 binds CDKN1A promoter (Mus musculus)
EP400 binds CDKN1A promoter (Rattus norvegicus)
EP400 binds CDKN1A promoter (Sus scrofa)
EP400 binds CDKN1A promoter (Xenopus tropicalis)
Authored
Orlic-Milacic, M (2013-09-30)
Reviewed
Samarajiwa, S (2013-09-03)
Created
Orlic-Milacic, M (2013-09-30)
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