PIAS4 SUMOylates TOP2A with SUMO2,3

Stable Identifier
R-HSA-4641350
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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PIAS4 SUMOylates TOP2A with SUMO2,3
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PIAS4 SUMOylates TOP2A with SUMO2,3 (Diaz-Martinez et al. 2006, Agostinho et al. 2008, Impens et al. 2014, Tammsalu et al. 2014). SUMOylation is observed in interphase and mitosis in response to inhibitors of topoisomerase. SUMOylated TOP2A is localized to centromeres during mitosis.
Literature References
PubMed ID Title Journal Year
18381449 Conjugation of human topoisomerase 2 alpha with small ubiquitin-like modifiers 2/3 in response to topoisomerase inhibitors: cell cycle stage and chromosome domain specificity

Agostinho, M, Santos, V, Ferreira, F, Costa, R, Cardoso, J, Pinheiro, I, Rino, J, Jaffray, E, Hay, RT, Ferreira, J

Cancer Res. 2008
24782567 Proteome-wide identification of SUMO2 modification sites

Tammsalu, T, Matic, I, Jaffray, EG, Ibrahim, AF, Tatham, MH, Hay, RT

Sci Signal 2014
17183683 PIASgamma is required for faithful chromosome segregation in human cells

Díaz-Martínez, LA, Giménez-Abián, JF, Azuma, Y, Guacci, V, Giménez-Martín, G, Lanier, LM, Clarke, DJ

PLoS ONE 2006
25114211 Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli

Impens, F, Radoshevich, L, Cossart, P, Ribet, D

Proc. Natl. Acad. Sci. U.S.A. 2014
Participants
Input
Output
Participates
as an event of
Event Information
Go Biological Process
protein sumoylation (0016925)
Catalyst Activity

SUMO transferase activity of PIAS4 [nucleoplasm]

Physical Entity
PIAS4 [nucleoplasm] (Homo sapiens)
Activity
SUMO transferase activity (GO:0019789)
Orthologous Events
PIAS4 SUMOylates TOP2A with SUMO2,3 (Bos taurus)
PIAS4 SUMOylates TOP2A with SUMO2,3 (Danio rerio)
PIAS4 SUMOylates TOP2A with SUMO2,3 (Dictyostelium discoideum)
PIAS4 SUMOylates TOP2A with SUMO2,3 (Drosophila melanogaster)
PIAS4 SUMOylates TOP2A with SUMO2,3 (Gallus gallus)
PIAS4 SUMOylates TOP2A with SUMO2,3 (Mus musculus)
PIAS4 SUMOylates TOP2A with SUMO2,3 (Rattus norvegicus)
PIAS4 SUMOylates TOP2A with SUMO2,3 (Xenopus tropicalis)
Authored
May, B  (2013-09-27)
Reviewed
Zhang, XD  (2015-10-04)
Created
May, B  (2013-09-28)
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