PIAS4 SUMOylates TOP2A with SUMO2,3

Stable Identifier
R-HSA-4641350
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
PIAS4 SUMOylates TOP2A with SUMO2,3
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
PIAS4 SUMOylates TOP2A with SUMO2,3 (Diaz-Martinez et al. 2006, Agostinho et al. 2008, Impens et al. 2014, Tammsalu et al. 2014). SUMOylation is observed in interphase and mitosis in response to inhibitors of topoisomerase. SUMOylated TOP2A is localized to centromeres during mitosis.
Literature References
PubMed ID Title Journal Year
18381449 Conjugation of human topoisomerase 2 alpha with small ubiquitin-like modifiers 2/3 in response to topoisomerase inhibitors: cell cycle stage and chromosome domain specificity

Rino, J, Santos, V, Pinheiro, I, Hay, RT, Jaffray, E, Costa, R, Ferreira, F, Cardoso, J, Ferreira, J, Agostinho, M

Cancer Res. 2008
24782567 Proteome-wide identification of SUMO2 modification sites

Tatham, MH, Hay, RT, Tammsalu, T, Ibrahim, AF, Jaffray, EG, Matic, I

Sci Signal 2014
17183683 PIASgamma is required for faithful chromosome segregation in human cells

Guacci, V, Lanier, LM, Giménez-Abián, JF, Díaz-Martínez, LA, Clarke, DJ, Giménez-Martín, G, Azuma, Y

PLoS ONE 2006
25114211 Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli

Impens, F, Cossart, P, Radoshevich, L, Ribet, D

Proc. Natl. Acad. Sci. U.S.A. 2014
Participants
Input
Output
Participates
as an event of
Event Information
Go Biological Process
protein sumoylation (0016925)
Catalyst Activity

SUMO transferase activity of PIAS4 [nucleoplasm]

Physical Entity
PIAS4 [nucleoplasm] (Homo sapiens)
Activity
SUMO transferase activity (GO:0019789)
Orthologous Events
PIAS4 SUMOylates TOP2A with SUMO2,3 (Bos taurus)
PIAS4 SUMOylates TOP2A with SUMO2,3 (Drosophila melanogaster)
PIAS4 SUMOylates TOP2A with SUMO2,3 (Gallus gallus)
PIAS4 SUMOylates TOP2A with SUMO2,3 (Mus musculus)
PIAS4 SUMOylates TOP2A with SUMO2,3 (Rattus norvegicus)
PIAS4 SUMOylates TOP2A with SUMO2,3 (Sus scrofa)
PIAS4 SUMOylates TOP2A with SUMO2,3 (Xenopus tropicalis)
Authored
May, B  (2013-09-27)
Reviewed
Zhang, XD  (2015-10-04)
Created
May, B  (2013-09-28)
Cite Us!