PIAS4 SUMOylates TOP2A with SUMO2,3

Stable Identifier
Reaction [transition]
Homo sapiens
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PIAS4 SUMOylates TOP2A with SUMO2,3 (Diaz-Martinez et al. 2006, Agostinho et al. 2008, Impens et al. 2014, Tammsalu et al. 2014). SUMOylation is observed in interphase and mitosis in response to inhibitors of topoisomerase. SUMOylated TOP2A is localized to centromeres during mitosis.
Literature References
PubMed ID Title Journal Year
18381449 Conjugation of human topoisomerase 2 alpha with small ubiquitin-like modifiers 2/3 in response to topoisomerase inhibitors: cell cycle stage and chromosome domain specificity

Rino, J, Santos, V, Pinheiro, I, Hay, RT, Jaffray, E, Costa, R, Ferreira, F, Cardoso, J, Ferreira, J, Agostinho, M

Cancer Res. 2008
24782567 Proteome-wide identification of SUMO2 modification sites

Tatham, MH, Hay, RT, Tammsalu, T, Ibrahim, AF, Jaffray, EG, Matic, I

Sci Signal 2014
17183683 PIASgamma is required for faithful chromosome segregation in human cells

Guacci, V, Lanier, LM, Giménez-Abián, JF, Díaz-Martínez, LA, Clarke, DJ, Giménez-Martín, G, Azuma, Y

PLoS ONE 2006
25114211 Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli

Impens, F, Cossart, P, Radoshevich, L, Ribet, D

Proc. Natl. Acad. Sci. U.S.A. 2014
Event Information
Go Biological Process
Catalyst Activity

SUMO transferase activity of PIAS4 [nucleoplasm]

Orthologous Events
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