Reactome | SUMOylation of TOP2A with SUMO1

SUMOylation of TOP2A with SUMO1

Stable Identifier

R-HSA-4641342

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

TOP2A is SUMOylated with SUMO1 (Mao et al. 2000, Dawlaty et al. 2008, Matafora et al. 2009, Impens et al. 2014). SUMOylation is observed in response to TOP2A-mediated DNA damage induced by teniposide.

Literature References

PubMed ID	Title	Journal	Year
18394993	Resolution of sister centromeres requires RanBP2-mediated SUMOylation of topoisomerase IIalpha Dawlaty, MM, Malureanu, L, Jeganathan, KB, Kao, E, Sustmann, C, Tahk, S, Shuai, K, Grosschedl, R, van Deursen, JM	Cell	2008
19596686	Proteomics analysis of nucleolar SUMO-1 target proteins upon proteasome inhibition Matafora, V, D'Amato, A, Mori, S, Blasi, F, Bachi, A	Mol. Cell Proteomics	2009
10862613	SUMO-1 conjugation to human DNA topoisomerase II isozymes Mao, Y, Desai, SD, Liu, LF	J. Biol. Chem.	2000
25114211	Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli Impens, F, Radoshevich, L, Cossart, P, Ribet, D	Proc. Natl. Acad. Sci. U.S.A.	2014