SUMOylation of TOP2A with SUMO1

Stable Identifier
Reaction [transition]
Homo sapiens
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TOP2A is SUMOylated with SUMO1 (Mao et al. 2000, Dawlaty et al. 2008, Matafora et al. 2009, Impens et al. 2014). SUMOylation is observed in response to TOP2A-mediated DNA damage induced by teniposide.

Literature References
PubMed ID Title Journal Year
18394993 Resolution of sister centromeres requires RanBP2-mediated SUMOylation of topoisomerase IIalpha

van Deursen, JM, Shuai, K, Kao, E, Jeganathan, KB, Tahk, S, Malureanu, L, Dawlaty, MM, Sustmann, C, Grosschedl, R

Cell 2008
19596686 Proteomics analysis of nucleolar SUMO-1 target proteins upon proteasome inhibition

Blasi, F, Mori, S, Bachi, A, Matafora, V, D'Amato, A

Mol. Cell Proteomics 2009
10862613 SUMO-1 conjugation to human DNA topoisomerase II isozymes

Mao, Y, Desai, SD, Liu, LF

J. Biol. Chem. 2000
25114211 Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli

Impens, F, Cossart, P, Radoshevich, L, Ribet, D

Proc. Natl. Acad. Sci. U.S.A. 2014
Event Information
Go Biological Process
Catalyst Activity

SUMO transferase activity of SUMO1:C93-UBE2I [cytoplasm]

Orthologous Events
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