PIAS1 SUMOylates SATB2 with SUMO3

Stable Identifier
R-HSA-4615900
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

PIAS1 SUMOylates SATB2 at lysine-233 and lysine-350 with SUMO3 (Dobreva et al. 2003, Lamoliatte et al. 2013, Lamoliatte et al. 2014). SUMOylation reduces binding of SATB2 to matrix attachment regions and reduces activation of transcription by SATB2. SUMOylated SATB2 is localized to the nuclear periphery.

Literature References
PubMed ID Title Journal Year
25391492 Large-scale analysis of lysine SUMOylation by SUMO remnant immunoaffinity profiling

Lamoliatte, F, Caron, D, Durette, C, Mahrouche, L, Maroui, MA, Caron-Lizotte, O, Bonneil, E, Chelbi-Alix, MK, Thibault, P

Nat Commun 2014
14701874 SUMO modification of a novel MAR-binding protein, SATB2, modulates immunoglobulin mu gene expression

Dobreva, G, Dambacher, J, Grosschedl, R

Genes Dev. 2003
23750026 Targeted identification of SUMOylation sites in human proteins using affinity enrichment and paralog-specific reporter ions

Lamoliatte, F, Bonneil, E, Durette, C, Caron-Lizotte, O, Wildemann, D, Zerweck, J, Wenshuk, H, Thibault, P

Mol. Cell Proteomics 2013
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
SUMO transferase activity of PIAS1 [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created