Reactome | PIAS1 SUMOylates SATB2 with SUMO3

PIAS1 SUMOylates SATB2 with SUMO3

Stable Identifier

R-HSA-4615900

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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PIAS1 SUMOylates SATB2 at lysine-233 and lysine-350 with SUMO3 (Dobreva et al. 2003, Lamoliatte et al. 2013, Lamoliatte et al. 2014). SUMOylation reduces binding of SATB2 to matrix attachment regions and reduces activation of transcription by SATB2. SUMOylated SATB2 is localized to the nuclear periphery.

Literature References

PubMed ID	Title	Journal	Year
14701874	SUMO modification of a novel MAR-binding protein, SATB2, modulates immunoglobulin mu gene expression Dambacher, J, Dobreva, G, Grosschedl, R	Genes Dev.	2003
25391492	Large-scale analysis of lysine SUMOylation by SUMO remnant immunoaffinity profiling Chelbi-Alix, MK, Durette, C, Bonneil, E, Lamoliatte, F, Maroui, MA, Caron-Lizotte, O, Caron, D, Thibault, P, Mahrouche, L	Nat Commun	2014
23750026	Targeted identification of SUMOylation sites in human proteins using affinity enrichment and paralog-specific reporter ions Zerweck, J, Wenshuk, H, Wildemann, D, Durette, C, Bonneil, E, Lamoliatte, F, Caron-Lizotte, O, Thibault, P	Mol. Cell Proteomics	2013