PIAS1 SUMOylates SATB2 with SUMO3

Stable Identifier
Reaction [transition]
Homo sapiens
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PIAS1 SUMOylates SATB2 at lysine-233 and lysine-350 with SUMO3 (Dobreva et al. 2003, Lamoliatte et al. 2013, Lamoliatte et al. 2014). SUMOylation reduces binding of SATB2 to matrix attachment regions and reduces activation of transcription by SATB2. SUMOylated SATB2 is localized to the nuclear periphery.

Literature References
PubMed ID Title Journal Year
14701874 SUMO modification of a novel MAR-binding protein, SATB2, modulates immunoglobulin mu gene expression

Dambacher, J, Dobreva, G, Grosschedl, R

Genes Dev. 2003
25391492 Large-scale analysis of lysine SUMOylation by SUMO remnant immunoaffinity profiling

Chelbi-Alix, MK, Durette, C, Bonneil, E, Lamoliatte, F, Maroui, MA, Caron-Lizotte, O, Caron, D, Thibault, P, Mahrouche, L

Nat Commun 2014
23750026 Targeted identification of SUMOylation sites in human proteins using affinity enrichment and paralog-specific reporter ions

Zerweck, J, Wenshuk, H, Wildemann, D, Durette, C, Bonneil, E, Lamoliatte, F, Caron-Lizotte, O, Thibault, P

Mol. Cell Proteomics 2013
Catalyst Activity

SUMO transferase activity of PIAS1 [nucleoplasm]

Orthologous Events
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