CBX4 (Pc2) SUMOylates HNRNPK with SUMO2

Stable Identifier
Reaction [transition]
Homo sapiens
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CBX4 (Pc2) SUMOylates HNRNPK at lysine-422 with SUMO2 (Li et al. 2004, Lee et al. 2012, Pelisch et al. 2012, Hendriks et al. 2014, Impens et al. 2014, Tammsalu et al. 2014). (Two molecules of SUMO2 are shown in the reaction in order to represent the oligomeric chains of SUMO2 that are attached to a target protein.) PIAS3 also SUMOylates HNRNPK predominantly with SUMO1 (Lee et al. 2012). HNRNPK is SUMOylated in response to DNA damage and SUMOylation is regulated by HIPK2 and CBX4. SUMOylation of HNRNPK is required for coactivation of TP53 (p53) activated transcription. SUMOylation increases the stability of HNRNPK, the nonSUMOylated form of which is normally ubiquinated by HDM2 (Lee et al. 2012).
Literature References
PubMed ID Title Journal Year
22825850 DNA damage-induced heterogeneous nuclear ribonucleoprotein K sumoylation regulates p53 transcriptional activation

Srebrow, A, Pelisch, F, Risso, G, Muñoz, MJ, Pozzi, B

J. Biol. Chem. 2012
24782567 Proteome-wide identification of SUMO2 modification sites

Tatham, MH, Hay, RT, Tammsalu, T, Ibrahim, AF, Jaffray, EG, Matic, I

Sci Signal 2014
15161980 Sumoylation of heterogeneous nuclear ribonucleoproteins, zinc finger proteins, and nuclear pore complex proteins: a proteomic analysis

Chao, CC, Li, T, Chock, PB, Shen, RF, Evdokimov, E, Tekle, E, Stadtman, ER, Yang, DC, Wang, T

Proc. Natl. Acad. Sci. U.S.A. 2004
25218447 Uncovering global SUMOylation signaling networks in a site-specific manner

Yang, B, Hendriks, IA, Verlaan-de Vries, M, Vertegaal, AC, D'Souza, RC, Mann, M

Nat. Struct. Mol. Biol. 2014
23092970 SUMOylation of hnRNP-K is required for p53-mediated cell-cycle arrest in response to DNA damage

Yoo, HM, Lee, MH, Kang, SH, Lee, SW, Ka, SH, Jeon, YJ, Chung, CH, Park, JH, Oh, YM

EMBO J. 2012
25114211 Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli

Impens, F, Cossart, P, Radoshevich, L, Ribet, D

Proc. Natl. Acad. Sci. U.S.A. 2014
Catalyst Activity

SUMO transferase activity of PRC1 complex [nucleoplasm]

Orthologous Events
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