Reactome | CBX4 (Pc2) SUMOylates HNRNPK with SUMO2

CBX4 (Pc2) SUMOylates HNRNPK with SUMO2

Stable Identifier

R-HSA-4570499

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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CBX4 (Pc2) SUMOylates HNRNPK at lysine-422 with SUMO2 (Li et al. 2004, Lee et al. 2012, Pelisch et al. 2012, Hendriks et al. 2014, Impens et al. 2014, Tammsalu et al. 2014). (Two molecules of SUMO2 are shown in the reaction in order to represent the oligomeric chains of SUMO2 that are attached to a target protein.) PIAS3 also SUMOylates HNRNPK predominantly with SUMO1 (Lee et al. 2012). HNRNPK is SUMOylated in response to DNA damage and SUMOylation is regulated by HIPK2 and CBX4. SUMOylation of HNRNPK is required for coactivation of TP53 (p53) activated transcription. SUMOylation increases the stability of HNRNPK, the nonSUMOylated form of which is normally ubiquinated by HDM2 (Lee et al. 2012).

Literature References

PubMed ID	Title	Journal	Year
22825850	DNA damage-induced heterogeneous nuclear ribonucleoprotein K sumoylation regulates p53 transcriptional activation Srebrow, A, Pelisch, F, Risso, G, Muñoz, MJ, Pozzi, B	J. Biol. Chem.	2012
24782567	Proteome-wide identification of SUMO2 modification sites Tatham, MH, Hay, RT, Tammsalu, T, Ibrahim, AF, Jaffray, EG, Matic, I	Sci Signal	2014
15161980	Sumoylation of heterogeneous nuclear ribonucleoproteins, zinc finger proteins, and nuclear pore complex proteins: a proteomic analysis Chao, CC, Li, T, Chock, PB, Shen, RF, Evdokimov, E, Tekle, E, Stadtman, ER, Yang, DC, Wang, T	Proc. Natl. Acad. Sci. U.S.A.	2004
25218447	Uncovering global SUMOylation signaling networks in a site-specific manner Yang, B, Hendriks, IA, Verlaan-de Vries, M, Vertegaal, AC, D'Souza, RC, Mann, M	Nat. Struct. Mol. Biol.	2014
23092970	SUMOylation of hnRNP-K is required for p53-mediated cell-cycle arrest in response to DNA damage Yoo, HM, Lee, MH, Kang, SH, Lee, SW, Ka, SH, Jeon, YJ, Chung, CH, Park, JH, Oh, YM	EMBO J.	2012
25114211	Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli Impens, F, Cossart, P, Radoshevich, L, Ribet, D	Proc. Natl. Acad. Sci. U.S.A.	2014