Cytosolic, non-phosphorylated PGYM dimers (b form) can reversibly bind AMP. This reaction is negatively regulated by ATP and glucose 6-phosphate and is the means by which high levels of these molecules repress PGYM activity (Rath et al. 2000).
Rath, VL, Ammirati, M, LeMotte, PK, Fennell, KF, Mansour, MN, Danley, DE, Hynes, TR, Schulte, GK, Wasilko, DJ, Pandit, J
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