PYGM dimer, b form + 2 AMP => PYGM b dimer:AMP complex

Stable Identifier
R-HSA-453342
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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PYGM dimer, b form + 2 AMP => PYGM b dimer:AMP complex
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Cytosolic, non-phosphorylated PGYM dimers (b form) can reversibly bind AMP. This reaction is negatively regulated by ATP and glucose 6-phosphate and is the means by which high levels of these molecules repress PGYM activity (Rath et al. 2000).
Literature References
PubMed ID Title Journal Year
10949035 Activation of human liver glycogen phosphorylase by alteration of the secondary structure and packing of the catalytic core

Rath, VL, Ammirati, M, LeMotte, PK, Fennell, KF, Mansour, MN, Danley, DE, Hynes, TR, Schulte, GK, Wasilko, DJ, Pandit, J

Mol Cell 2000
Participants
Input
Output
Participates
as an event of
Catalyst Activity

AMP binding activity of PYGM dimer, b form [cytosol]

Physical Entity
PYGM dimer, b form [cytosol] (Homo sapiens)
Activity
AMP binding (GO:0016208)
This event is regulated
Negatively by
Regulator
G6P [cytosol]
Regulator
ATP [cytosol]
Orthologous Events
PYGM dimer, b form + 2 AMP => PYGM b dimer:AMP complex (Bos taurus)
PYGM dimer, b form + 2 AMP => PYGM b dimer:AMP complex (Caenorhabditis elegans)
PYGM dimer, b form + 2 AMP => PYGM b dimer:AMP complex (Canis familiaris)
PYGM dimer, b form + 2 AMP => PYGM b dimer:AMP complex (Danio rerio)
PYGM dimer, b form + 2 AMP => PYGM b dimer:AMP complex (Dictyostelium discoideum)
PYGM dimer, b form + 2 AMP => PYGM b dimer:AMP complex (Drosophila melanogaster)
PYGM dimer, b form + 2 AMP => PYGM b dimer:AMP complex (Mus musculus)
PYGM dimer, b form + 2 AMP => PYGM b dimer:AMP complex (Rattus norvegicus)
PYGM dimer, b form + 2 AMP => PYGM b dimer:AMP complex (Saccharomyces cerevisiae)
PYGM dimer, b form + 2 AMP => PYGM b dimer:AMP complex (Sus scrofa)
PYGM dimer, b form + 2 AMP => PYGM b dimer:AMP complex (Xenopus tropicalis)
PYGB dimer, b form + 2 AMP => PYGB b dimer:AMP complex (Homo sapiens)
Authored
D'Eustachio, P  (2010-01-22)
Reviewed
Hill, DP  (2025-06-02)
Created
D'Eustachio, P  (2010-01-22)
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