PGYM dimer, b form + 2 AMP <=> PGYM b dimer:AMP complex

Stable Identifier
R-HSA-453342
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
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PGYM dimer, b form + 2 AMP <=> PGYM b dimer:AMP complex
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Cytosolic, non-phosphorylated PGYM dimers (b form) can reversibly bind AMP. This reaction is negatively regulated by ATP and glucose 6-phosphate and is the means by which high levels of these molecules repress PGYM activity (Rath et al. 2000).

Literature References
PubMed ID Title Journal Year
10949035 Activation of human liver glycogen phosphorylase by alteration of the secondary structure and packing of the catalytic core

Rath, VL, Ammirati, M, LeMotte, PK, Fennell, KF, Mansour, MN, Danley, DE, Hynes, TR, Schulte, GK, Wasilko, DJ, Pandit, J

Mol Cell 2000
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Output
Participant Of
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Event Information
Reverse Reaction
PGYM b dimer:AMP complex <=> PGYM dimer, b form + 2 AMP (Homo sapiens)
This event is regulated
Negatively by
Orthologous Events
PGYB dimer, b form + 2 AMP <=> PGYB b dimer:AMP complex (Homo sapiens)
PGYM dimer, b form + 2 AMP <=> PGYM b dimer:AMP complex (Bos taurus)
PGYM dimer, b form + 2 AMP <=> PGYM b dimer:AMP complex (Caenorhabditis elegans)
PGYM dimer, b form + 2 AMP <=> PGYM b dimer:AMP complex (Canis familiaris)
PGYM dimer, b form + 2 AMP <=> PGYM b dimer:AMP complex (Danio rerio)
PGYM dimer, b form + 2 AMP <=> PGYM b dimer:AMP complex (Dictyostelium discoideum)
PGYM dimer, b form + 2 AMP <=> PGYM b dimer:AMP complex (Drosophila melanogaster)
PGYM dimer, b form + 2 AMP <=> PGYM b dimer:AMP complex (Mus musculus)
PGYM dimer, b form + 2 AMP <=> PGYM b dimer:AMP complex (Rattus norvegicus)
PGYM dimer, b form + 2 AMP <=> PGYM b dimer:AMP complex (Saccharomyces cerevisiae)
PGYM dimer, b form + 2 AMP <=> PGYM b dimer:AMP complex (Sus scrofa)
PGYM dimer, b form + 2 AMP <=> PGYM b dimer:AMP complex (Xenopus tropicalis)
Authored
D'Eustachio, P  (2010-01-22)
Created
D'Eustachio, P  (2010-01-22)