Heterodimerization of nephrin and KIRREL2, KIRREL3

Stable Identifier
R-HSA-451757
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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NEPH2 and NEPH3 specifically interact with the extracellular domains of nephrin in the slit diaphragm of podocytes and potentially other tissues as well (eg. brain). The functional significance of these interactions is unknown.

Literature References
PubMed ID Title Journal Year
15843475 NEPH2 is located at the glomerular slit diaphragm, interacts with nephrin and is cleaved from podocytes by metalloproteinases

Gerke, P, Sellin, L, Kretz, O, Petraschka, D, Zentgraf, H, Benzing, T, Walz, G

J Am Soc Nephrol 2005
20233749 A model organism approach: defining the role of Neph proteins as regulators of neuron and kidney morphogenesis

Neumann-Haefelin, E, Kramer-Zucker, A, Slanchev, K, Hartleben, B, Noutsou, F, Martin, K, Wanner, N, Ritter, A, Gödel, M, Pagel, P, Fu, X, Müller, A, Baumeister, R, Walz, G, Huber, TB

Hum Mol Genet 2010
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